294648-66-1
294648-66-1
Chemical Structure
ADAMTS-5-IN-2
- CAS No.: 294648-66-1
- Formula:C17H15N3OS
- Molecular Weight:309.39
IUPAC Name: 5-ethyl-5'-phenyl-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one
InChIKey: ICJWVAKZQXYHBB-UHFFFAOYSA-N
SMILES: O=C1NC2=C(C=C(CC)C=C2)C13SC(C4=CC=CC=C4)=NN3
Biological Activity: ADAMTS-5-IN-2 is an inhibitor of ADAMTS-5 (IC50: 9.6 μM) and BoNT/A LC (IC50: 0.71 μM). ADAMTS-5-IN-2 can be used in research related to botulism, osteoarthritis, and other conditions[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ADAMTS-5-IN-2 | 98.73% | ADAMTS-5-IN-2 is an inhibitor of ADAMTS-5 (IC50: 9.6 μM) and BoNT/A LC (IC50: 0.71 μM). ADAMTS-5-IN-2 can be used in research related to botulism, osteoarthritis, and other conditions. | ||||||||||||||||||||
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References
- [1]. Bompiani KM, et al. High-Throughput Screening Uncovers Novel Botulinum Neurotoxin Inhibitor Chemotypes. ACS Comb Sci. 2016;18(8):461-474. [Content Brief]
- [2]. Bursavich MG, et al. 5'-Phenyl-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (aggrecanase-2). Bioorg Med Chem Lett. 2007;17(20):5630-5633. [Content Brief]
