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ADAMTS-5 Inhibitor 

Cat. No.: HY-114996 Purity: 99.50%
Handling Instructions

ADAMTS-5 Inhibitor is a potent ADAMTS-5 (aggrecanase-2) inhibitor, with an IC50 of 1.1 µM. ADAMTS-5 Inhibitor shows >40-fold functional selectivity over ADAMTS-4 (aggrecanase-1).

For research use only. We do not sell to patients.

ADAMTS-5 Inhibitor Chemical Structure

ADAMTS-5 Inhibitor Chemical Structure

CAS No. : 929634-33-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 275 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 450 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1350 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

ADAMTS-5 Inhibitor is a potent ADAMTS-5 (aggrecanase-2) inhibitor, with an IC50 of 1.1 µM. ADAMTS-5 Inhibitor shows >40-fold functional selectivity over ADAMTS-4 (aggrecanase-1)[1].

In Vitro

ADAMTS-5 (aggrecanase-2) is an extracellular matrix-degrading protease implicated in cartilage destruction in arthritis[2].

Molecular Weight

449.92

Formula

C₁₆H₁₁ClF₃N₃OS₃

CAS No.

929634-33-3

SMILES

O=C1NC(S/C1=C\C2=C(SCC3=CC=C(Cl)C=C3)N(C)N=C2C(F)(F)F)=S

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (185.21 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2226 mL 11.1131 mL 22.2262 mL
5 mM 0.4445 mL 2.2226 mL 4.4452 mL
10 mM 0.2223 mL 1.1113 mL 2.2226 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

ADAMTS-5 InhibitorOthersextracellularmatrix-degradingproteasecartilagedestructionarthritisInhibitorinhibitorinhibit

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Product name:
ADAMTS-5 Inhibitor
Cat. No.:
HY-114996
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