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ActRIIB

" in MedChemExpress (MCE) Product Catalog:

By Targets:	TGF-beta/Smad (1) TGF-β Receptor (3)
By Research Areas:	Metabolic Disease (4)

4

Inhibitors & Agonists

4

Inhibitory Antibodies

8

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Bimagrumab 1 Publications Verification Anti-ACVR2B Reference Antibody; BYM338	TGF-β Receptor	Metabolic Disease
Bimagrumab (Anti-ACVR2B Reference Antibody) is a human monoclonal antibody that blocks activin type II receptor (ActRII), with K_Ds of 1.7 pM and 434 pM for human *ActRIIB* and ActRIIA, respectively. Bimagrumab can be used for the research of pathological muscle loss and weakness .

Luspatercept ACE-536; luspatercept–aamt	TGF-beta/Smad	Metabolic Disease
Luspatercept (ACE-536) is a recombinant modified ActRIIB fusion protein that binds with transforming growth factor β superfamily ligands. Luspatercept increases the erythrocyte numbers and promotes maturation of erythroid precursors. Luspatercept binds with GDF11 and inhibits Smad2/3 signaling. Luspatercept can be used for the research of anemia .

Stamulumab MYO-029	TGF-β Receptor	Metabolic Disease
Stamulumab (MYO-029) is a recombinant human IgG1λ antibody that binds to myostatin and neutralizes its activity by preventing binding to its endogenous high-affinity receptor ActRIIB. Stamulumab leads to muscle fiber hypertrophy and not hyperplasia in SCID mice. Stamulumab has the potential for Becker muscular dystrophy (BMD), facioscapulohumeral dystrophy (FSHD), and limb-girdle muscular dystrophy (LGMD) research .

Ramatercept	TGF-β Receptor	Metabolic Disease
Ramatercept is a soluble ActRIIB receptor and can be used as a soluble activin receptor 2 (ACVR2) antagonist. Ramatercept inhibits the signal pathway of muscle growth inhibition and has potential application in muscle atrophy .

Species:	Human (3) Mouse (2) Cynomolgus (3)
Tag:	His (5) Tag Free (1) Fc (3)
Source:	HEK293 (7) P. pastoris (1)

Cat. No.	Compare	Product Name	Species	Source

	ACVR2B Protein, Mouse (HEK293, His) Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B	Mouse	HEK293
	ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Mouse (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag. It consists of 134 amino acids (M1-T134).

	ACVR2B Protein, Human (P. pastoris, N-His) Activin receptor type IIB; ACTR-IIB	Human	P. pastoris
	ACVR2B is a transmembrane kinase that forms the activin receptor complex and is essential for transducing activin signals. It regulates diverse processes including neuronal differentiation, hair follicle development, FSH production, wound healing, matrix production, immunosuppression, and carcinogenesis. ACVR2B Protein, Human (P. pastoris, N-His) is the recombinant human-derived ACVR2B protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of ACVR2B Protein, Human (P. pastoris, N-His) is 119 a.a., with molecular weight of 15.7 kDa.

	ACVR2B Protein, Mouse (HEK293, His-hFc) Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B	Mouse	HEK293
	ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Mouse (HEK293, His-hFc) is produced in HEK293 cells with a C-Terminal His-tag and a C-Terminal Fc-tag. It consists of 134 amino acids (M1-T134).

	ACVR2B Protein, Cynomolgus (HEK293, His) Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B	Cynomolgus	HEK293
	ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Cynomolgus (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag. It consists of 116 amino acids (S28-M143).

	ACVR2B Protein, Cynomolgus (HEK293, Fc) Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B	Cynomolgus	HEK293
	ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Cynomolgus (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 116 amino acids (S28-M143).

	ACVR2B Protein, Human (HEK293, Fc) Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B	Human	HEK293
	ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Human (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 134amino acids (M1-T134).

	ACVR2B Protein, Cynomolgus (HEK293) Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B	Cynomolgus	HEK293
	ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Cynomolgus (HEK293) is produced in HEK293 cells,and consists of 116 amino acids (S28-M143).

	ACVR2B Protein, Human (HEK293, His) rHuActivin receptor type 2B, His; ACVR-2B; Activin receptor type 2B	Human	HEK293
	ACVR2B is a type II member of the TGF-β family of receptor Serine/Threonine kinases. ACVR2B binds to activins and growth differentiation factors (GDF), which in turn activate type I receptors, activating downstream molecule SMAD2/3. ACVR2B Protein, Human (HEK293, His) is produced in HEK293 cells with six C-Terminal His-tags. It consists of 116 amino acids (S19-T134).

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