2. TGF-beta/Smad
  3. TGF-β Receptor
  4. Stamulumab

Stamulumab  (Synonyms: MYO-029)

Cat. No.: HY-P99588

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Stamulumab (MYO-029) is a recombinant human IgG1λ antibody that binds to myostatin and neutralizes its activity by preventing binding to its endogenous high-affinity receptor ActRIIB. Stamulumab leads to muscle fiber hypertrophy and not hyperplasia in SCID mice. Stamulumab has the potential for Becker muscular dystrophy (BMD), facioscapulohumeral dystrophy (FSHD), and limb-girdle muscular dystrophy (LGMD) research.

For research use only. We do not sell to patients.

Stamulumab Chemical Structure

Stamulumab Chemical Structure

CAS No. : 705287-60-1

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Stamulumab Related Antibodies

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Description

Stamulumab (MYO-029) is a recombinant human IgG1λ antibody that binds to myostatin and neutralizes its activity by preventing binding to its endogenous high-affinity receptor ActRIIB. Stamulumab leads to muscle fiber hypertrophy and not hyperplasia in SCID mice. Stamulumab has the potential for Becker muscular dystrophy (BMD), facioscapulohumeral dystrophy (FSHD), and limb-girdle muscular dystrophy (LGMD) research[1][2].

In Vivo

Stamulumab (MYO-029; ip; 1-10 mg/kg/week for 12 weeks) increases skeletal muscle mass in vivo in a concentration-dependent manner in SCID mice. Stamulumab leads to muscle fiber hypertrophy and not hyperplasia[1].
Stamulumab (i.v.; 1, 5, 20, 100 mg/kg/week for 4 weeks) has a central clearance (CL) of 0.25 mL/h/kg in C57/SCID mice[1].
Pharmacokinetic Parameters of Stamulumab (MYO-029)[1].

C57/SCID mice IV (1-100 mg/kg/week for 4 weeks) Sprague Dawley rats (2-50 mg/kg; single injection) Cynomolgus monkeys (10-100 mg/kg/week for 5 or 39 weeks)
CL (mL/h/kg) 0.245 0.542 0.228
Volume of central compartment (mL/kg) 103 58.9 41.8
Distributive clearance (mL/h/kg) 1.79 0.815

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female SCID mice[1]
Dosage: 1, 2.5, 5, 10 mg/kg
Administration: IP; every week for 12 weeks
Result: Increased skeletal muscle mass in vivo in a concentration‐dependent manner.
Clinical Trial
CAS No.
SMILES

[Stamulumab]
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Stamulumab Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Stamulumab705287-60-1MYO-029MYO029MYO 029TGF-β ReceptorTransforming growth factor beta receptorsIgG1λmyostatinActRIIBmuscle fiber hypertrophyBecker muscular dystrophyBMDfacioscapulohumeral dystrophyFSHDlimb-girdle muscular dystrophyLGMDInhibitorinhibitorinhibit

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