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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
Apo-IDO1
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "Apo-IDO1" in MCE Product Catalog:
2
Research Areas:
LY-3381916 (IDO1-IN-5) is a potent, selective and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1 [1].
1
1 Cited Publications
Synonyms: (S)-IDO1-IN-5
Research Areas:
(S)-LY-3381916 ((S)-IDO1-IN-5; Example 1B) is an active S-isomer of LY-3381916. (S)-LY-3381916 binds to IDOL with an IC50 value less than 1.5 µΜ [1]. LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1 .
Cat. No.: HY-177784
Research Areas:
iDeg-3 is a potent IDO1 molecular glue degrader. iDeg-3 binds to apo-IDO1 and alters its C-terminal conformation, promoting CRL2-KLHDC3 E3 ligase-mediated ubiquitination and degradation of IDO1. iDeg-3 is suitable for cancer-related research [1].
Cat. No.: HY-178011
CAS No.: 1219296-74-8
Research Areas:
IDO1-IN-28 (Compound MQ-1) is a Apo-IDO1 inhibitor with an IC50 of 1.29 μM. IDO1-IN-28 selectively targets apo-IDO1 and disrupts heme binding. IDO1-IN-28 can be used for cancers research [1].
Cat. No.: HY-178024
CAS No.: 1219340-38-1
Research Areas:
IDO1-IN-29 (Compound MQ-1n) is a Apo-IDO1 inhibitor with an IC50 of 0.29 μM. IDO1-IN-29 selectively targets apo-IDO1 and disrupts heme binding. IDO1-IN-29 can be used for cancers research [1].
Cat. No.: HY-177783
Research Areas:
iDeg-1 is a potent IDO1 molecular glue degrader. iDeg-1 binds to apo-IDO1 and alters its C-terminal conformation, promoting CRL2-KLHDC3 E3 ligase-mediated ubiquitination and degradation of IDO1. iDeg-1 can be used in cancer-related research [1].
Cat. No.: HY-172453
Research Areas:
XW-032 is an apo-IDO1 inhibitor, with an IC50 of 21 nM. XW-032 (TGI = 63%) exhibits potent in vivo anti-tumor efficacy in the CT26 syngeneic mouse model and is expected to be applied in the research of the field of cancer [1].
Cat. No.: HY-178954
CAS No.: 2456309-77-4
Research Areas:
IDO1-IN-32 (Compound 45) is a potent and orally effective IDO1 inhibitor with an IC50 of 10 pM. IDO1-IN-32 exhibits significant anti-proliferative activity against Hela cells. IDO1-IN-32 can significantly inhibit tumor growth in CT26 and LCC transplanted mouse models by activating anti-tumor immunity. IDO1-IN-32 can be used for research on colon cancer and breast cancer [1].
Synonyms: (Rac)-IDO1-IN-5
Research Areas:
(Rac)-LY-3381916 ((Rac)-IDO1-IN-5; Example 1) is a racemate of LY-3381916 [1]. LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1 .
Cat. No.: HY-181947
Research Areas:
IDO1-IN-33 (Compound YC-16) is a IDO1 inhibitor (with an IC50 of 0.18 μM for IDO1 in HeLa cells). IDO1-IN-33 acts as an apo-IDO1 inhibitor by slowly and competitively displacing heme from mature holo-IDO1 and rapidly binding to the heme-binding site of immature apo-IDO1, without altering the expression level of IDO1. IDO1-IN-33 can be used for the research of hepatocellular carcinoma, non-small cell lung cancer, triple-negative breast cancer, and cervical cancer [1].
Cat. No.: HY-111540R
CAS No.: 2166616-75-5
Synonyms: IDO1-IN-5 (Standard)
Research Areas:
LY-3381916 (Standard) is the analytical standard of LY-3381916 (HY-111540). This product is intended for research and analytical applications. LY-3381916 (IDO1-IN-5) is a potent, selective and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacKing heme rather than mature heme-bound IDO1 [1].
Cat. No.: HY-111540AR
CAS No.: 2166616-74-4
Synonyms: (Rac)-IDO1-IN-5 (Standard)
Research Areas:
(Rac)-LY-3381916 (Standard) is the analytical standard of (Rac)-LY-3381916 (HY-111540A). This product is intended for research and analytical applications. (Rac)-LY-3381916 ((Rac)-IDO1-IN-5; Example 1) is a racemate of LY-3381916 [1]. LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacKing heme rather than mature heme-bound IDO1 .
Cat. No.: HY-111540BR
CAS No.: 2166616-76-6
Synonyms: (S)-IDO1-IN-5 (Standard)
Research Areas:
(S)-LY-3381916 (Standard) is the analytical standard of (S)-LY-3381916 (HY-111540B). This product is intended for research and analytical applications. (S)-LY-3381916 ((S)-IDO1-IN-5; Example 1B) is an active S-isomer of LY-3381916. (S)-LY-3381916 binds to IDOL with an IC50 value less than 1.5 µΜ [1]. LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacKing heme rather than mature heme-bound IDO1 .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
