IDO1-IN-33
IDO1-IN-33 (Compound YC-16) is a IDO1 inhibitor (with an IC50 of 0.18 μM for IDO1 in HeLa cells). IDO1-IN-33 acts as an apo-IDO1 inhibitor by slowly and competitively displacing heme from mature holo-IDO1 and rapidly binding to the heme-binding site of immature apo-IDO1, without altering the expression level of IDO1. IDO1-IN-33 can be used for the research of hepatocellular carcinoma, non-small cell lung cancer, triple-negative breast cancer, and cervical cancer.
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- Formule: C25H25ClN4O
- Masse moléculaire:432.95
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
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- Pureté et documentation
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
IDO1 0.18 μM (IC50) |
In Vitro
IDO1-IN-33 (0.5 μM) potently inhibits IDO1 activity in HeLa cells, with an IC50 of 0.18 ± 0.01 μM, and shows no significant cytotoxicity[1].
IDO1-IN-33 (48 h) potently inhibits IDO1 activity in multiple human tumor cell lines (HepG2, A549, MDA-MB-231), with corresponding IC50 values of 216.25 ± 12.8 nM, 115.9 ± 1.13 nM and 135.25 ± 12.37 nM, respectively, and shows no significant cytotoxicity[1].
IDO1-IN-33 (0.05-0.4 μM; 48 h) does not regulate the expression of IDO1 mRNA in HeLa cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 432.95
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Formule C25H25ClN4O
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SMILES
CCCC(NC(C1=CC=C(Cl)C=C1)=O)C(N=C2)=CN2CCC3=CC=NC4=C3C=CC=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IDO1-IN-33 Related Classifications
HY-181947 Related Classifications
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