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BMX-IN-1

" in MedChemExpress (MCE) Product Catalog:
製品番号 製品名 Target 研究分野 構造式
  • HY-80002
    BMX-IN-1
    5+ Cited Publications

    BMX kINase INhibitor

    		 Btk BMX Kinase Cancer
    BMX-IN-1 is a selective, irreversible inhibitor of bone marrow tyrosine kinase on chromosome X (BMX) that targets Cys 496 in the BMX ATP binding domain with an IC50 of 8 nM, also targets the related Bruton’s tyrosine kinase (BTK) with an IC50 value of 10.4 nM, but is more than 47-656-fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity.
    BMX-IN-1
  • HY-184006
    BMX ligand-1

    		BMX Kinase Ligands for Target Protein for PROTAC Cancer
    BMX ligand-1 (Compound 9) is a BMX ligand. BMX ligand-1 serves as a target protein ligand for the synthesis of BMX PROTAC degraders, such as IHMT-BMX-068 (HY-184005). BMX ligand-1 is applicable to prostate cancer research [1].
    BMX ligand-1
  • HY-182902
    IHMT-15137

    		BMX Kinase Apoptosis Cancer
    IHMT-15137 is a BMX inhibitor with an IC50 of 26.97 nM. IHMT-15137 covalently binds to BMX Cys496 within the ATP-binding pocket, inhibits BMX phosphorylation at Tyr566, and disrupts the BMX-ERK1/2-Cyclin D1/CDK4/6-E2F1 signaling axis. IHMT-15137 reduces E2F1 protein stability via decreased Ser332/337 phosphorylation, increased ubiquitination, and ubiquitin-proteasome pathway degradation. IHMT-15137 induces cell cycle arrest, apoptosis, DNA damage, and suppresses cell migration and invasion. IHMT-15137 can be used for the research of small cell lung cancer [1].
    IHMT-15137

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