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CD6

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CD6 (1) Cytochrome P450 (2) FGFR (1) Isotope-Labeled Compounds (3) Leukotriene Receptor (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (2) Metabolic Disease (1)

7

Inhibitors & Agonists

1

Inhibitory Antibodies

10

Recombinant Proteins

3

Isotope-Labeled Compounds

Targets Recommended: CD6

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Itolizumab Anti-Human CD6 Recombinant Antibody	CD6	Infection Inflammation/Immunology
Itolizumab (Anti-Human CD6 Recombinant Antibody) is a humanized recombinant *anti-CD6* monoclonal antibody (MAb) targeting the extracellular SRCR distal domain 1 of CD6. Itolizumab reduces T-cell proliferation and inhibits the production of pro-inflammatory cytokines, such as INF-γ, TNFα and IL-6. Itolizumab can be used in the research of psoriasis, rheumatoid arthritis (RA), COVID-19 .

Riociguat-13C,d6 BAY 632521-¹³C,d₆	Isotope-Labeled Compounds	Cardiovascular Disease
Riociguat- ¹³C,d₆ is the ¹³C and deuterium labeled Riociguat (HY-14779). Riociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.

CD6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CD6 Human Pre-designed siRNA Set A contains three designed siRNAs for CD6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CD6 Human Pre-designed siRNA Set A CD6 Human Pre-designed siRNA Set A

CYP2A6-IN-1	Cytochrome P450	Metabolic Disease
CD-6 is a flavonoid CYP2A6 inhibitor (IC₅₀: 1.566 μM). *CYP2A6* inhibits the metabolism of nicotine to cotinine, resulting in an increase in the amount of nicotine available in the blood, leading to increased smoking behavior. CD-6 mediates CYP2A6 inhibition and can be used in research on smoking cessation or smoking-related diseases .

HY-W294556S

1-Benzyl-4-methylenepiperidine-13C, d6

Isotope-Labeled Compounds Others

1-Benzyl-4-methylenepiperidine- ¹³C,d₆ is the deuterium and ¹³C labeled 1-Benzyl-4-methylenepiperidine[1].

Zafirlukast-13C,d6 ICI 204219-¹³C,d₆	Isotope-Labeled Compounds Leukotriene Receptor	Inflammation/Immunology Cancer
Zafirlukast- ¹³C,d₆ is the ¹³C- and deuterium labeled Zafirlukast. Zafirlukast (ICI 204219) is a potent orally active leukotriene D4 (LTD4) receptor antagonist. Zafirlukast shows anti-asthmatic, anti-inflammatory and anti-bacterial effects.

FGFR-IN-10	FGFR Cytochrome P450	Cancer
FGFR-IN-10 is an orally active inhibitor of FGFR and Cytochrome P450 (CYPs). FGFR-IN-10 inhibits wide type and V564F mutant FGFR2 with IC₅₀s of 104.1 nM and 43.6 nM, respectively. FGFR-IN-10 also inhibits CYPs with IC₅₀s of 3.33 μM (CYP2C9), 18.75 μM (CYP2C19), 4.34 μM (CYP2CD6), and 0.69 μM (CYP3A4), respectively .

Recombinant Proteins Recommended:

CD6

Species:	Human (4) Mouse (5) Rat (1)
Tag:	His (8) Avi (2) Fc (2)
Source:	HEK293 (10)

Cat. No.	Compare	Product Name	Species	Source

	CD6 Protein, Mouse (379a.a, HEK293, His) CD6 antigen; CD6	Mouse	HEK293
	CD6 is missing critical conserved residue(s) necessary for feature annotation propagation. CD6 Protein, Mouse (379a.a, HEK293, His) is the recombinant mouse-derived CD6 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CD6 Protein, Mouse (379a.a, HEK293, His) is 379 a.a., with molecular weight of 60-90 kDa.

	CD6 Protein, Human (HEK293, Fc) T-cell differentiation antigen CD6; T12; TP120; CD6	Human	HEK293
	The CD6 protein is a cell adhesion molecule that mediates cell-cell contacts and regulates T cell responses through interaction with ALCAM/CD166. It functions as a costimulatory molecule, promoting T cell activation, proliferation, and contributing to the formation of immune synapses. CD6 Protein, Human (HEK293, Fc) is the recombinant human-derived CD6 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD6 Protein, Human (HEK293, Fc) is 381 a.a., with molecular weight of ~67.3 kDa.

	CD6 Protein, Rat (HEK293, His) T-cell differentiation antigen CD6; T12; TP120; CD6	Rat	HEK293
	CD6, a protein, lacks essential conserved residue(s) necessary for propagating feature annotation. CD6 Protein, Rat (HEK293, His) is the recombinant rat-derived CD6 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD6 Protein, Rat (HEK293, His) is 379 a.a., with molecular weight of ~60-90 kDa.

	CD6 Protein, Mouse (HEK293, Fc) T-cell differentiation antigen CD6; T12; TP120; CD6	Mouse	HEK293
	CD6 is missing critical conserved residue(s) necessary for feature annotation propagation. CD6 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CD6 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD6 Protein, Mouse (HEK293, Fc) is 243 a.a., with molecular weight of 80-90 kDa.

	CD6 Protein, Mouse (396a.a, HEK293, His) T-cell differentiation antigen CD6; T12; TP120; CD6	Mouse	HEK293
	CD6 is missing critical conserved residue(s) necessary for feature annotation propagation. CD6 Protein, Mouse (396a.a, HEK293, His) is the recombinant mouse-derived CD6 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD6 Protein, Mouse (396a.a, HEK293, His) is 396 a.a., with molecular weight of 60-70 kDa.

	CD6 Protein, Human (HEK293, His) CD6; TP120; T12	Human	HEK293
	The CD6 protein is located on the outer membrane of T lymphocytes and other immune cells. It has three cysteine-rich scavenger receptor (SRCR) domains and a binding site for activated leukocyte cell adhesion molecules. CD6 Protein, Human (HEK293, His) is the recombinant human-derived CD6 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD6 Protein, Human (HEK293, His) is 385 a.a., with molecular weight of 70-90 kDa.

	ALCAM/CD166 Protein, Mouse (HEK293, His) CD166; ALCAM; MEMD; CD6L; KG-CAM	Mouse	HEK293
	The ALCAM/CD166 protein is a cell adhesion molecule that coordinates heterotypic and homotypic cell interactions, particularly with CD6. It promotes T cell activation, immune synapse formation, dendritic cell attachment, and inhibits endothelial cell migration while promoting tube formation. ALCAM/CD166 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ALCAM/CD166 protein, expressed by HEK293 , with C-His labeled tag. The total length of ALCAM/CD166 Protein, Mouse (HEK293, His) is 500 a.a., with molecular weight of 70-100 kDa.

	ALCAM/CD166 Protein, Human (Biotinylated, HEK293, His) CD166; ALCAM; MEMD; CD6L; KG-CAM	Human	HEK293
	The ALCAM/CD166 protein is a cell adhesion molecule that mediates heterotypic and homotypic cell-to-cell contacts, promoting T cell activation, immune synapse formation, and LILRB4-mediated inhibition of T cell proliferation. ALCAM/CD166 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived ALCAM/CD166 protein, expressed by HEK293 , with C-His labeled tag. The total length of ALCAM/CD166 Protein, Human (Biotinylated, HEK293, His) is 499 a.a., with molecular weight of 70-80 kDa.

	ALCAM/CD166 Protein, Human (Biotinylated, HEK293, His-Avi) CD166; ALCAM; MEMD; CD6L; KG-CAM	Human	HEK293
	The ALCAM/CD166 protein is a cell adhesion molecule that mediates heterotypic and homotypic cell-to-cell contacts, promoting T cell activation, immune synapse formation, and LILRB4-mediated inhibition of T cell proliferation. ALCAM/CD166 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived ALCAM/CD166 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of ALCAM/CD166 Protein, Human (Biotinylated, HEK293, His-Avi) is 499 a.a., with molecular weight of 72-80 kDa.

	ALCAM/CD166 Protein, Mouse (Biotinylated, HEK293, His-Avi) CD166; ALCAM; MEMD; CD6L; KG-CAM	Mouse	HEK293
	The ALCAM/CD166 protein is a cell adhesion molecule that coordinates heterotypic and homotypic cell interactions, particularly with CD6. It promotes T cell activation, immune synapse formation, dendritic cell attachment, and inhibits endothelial cell migration while promoting tube formation. ALCAM/CD166 Protein, Mouse (Biotinylated, HEK293, His-Avi) is the recombinant mouse-derived ALCAM/CD166 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of ALCAM/CD166 Protein, Mouse (Biotinylated, HEK293, His-Avi) is 500 a.a., with molecular weight of 75-85 kDa.

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