CD6 Protein, Human (HEK293, His)
Based on 1 Customer Validation
The CD6 protein is located on the outer membrane of T lymphocytes and other immune cells. It has three cysteine-rich scavenger receptor (SRCR) domains and a binding site for activated leukocyte cell adhesion molecules. CD6 Protein, Human (HEK293, His) is the recombinant human-derived CD6 protein, expressed by HEK293 , with C-His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
The CD6 protein is located on the outer membrane of T lymphocytes and other immune cells. It has three cysteine-rich scavenger receptor (SRCR) domains and a binding site for activated leukocyte cell adhesion molecules. CD6 Protein, Human (HEK293, His) is the recombinant human-derived CD6 protein, expressed by HEK293 , with C-His labeled tag.
The CD6 protein is situated on the outer membrane of T-lymphocytes and various other immune cells. Featuring three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule, this protein plays a crucial role in sustaining T cell activation. Additionally, there is evidence suggesting an association between this gene and susceptibility to multiple sclerosis. Multiple transcript variants, encoding diverse isoforms, have been identified for this gene, with biased expression observed in lymph node, appendix, and nine other tissues.
Immobilized Human CD6, His Tag at 1 or 2 μg/mL (100 μL/well) on the plate. Dose response curve for Human ALCAM, hFc Tag with the EC50 of ≤6.3 ng/mL determined by ELISA.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-8*His
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Accession
NP_006716.3 (H18-L402)
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Molecular Construction
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N-term
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CD6 (H18-L402)
Accession # NP_006716.3 -
8*His
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C-term
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Protein Length
Partial
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Synonyms
CD6; Tp120; CD6 Molecule; T12; T-Cell Differentiation Antigen CD6; Alternative Protein CD6; CD6 Antigen; TP120
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AA Sequence
HPSPAPPDQLNTSSAESELWEPGERLPVRLTNGSSSCSGTVEVRLEASWEPACGALWDSRAAEAVCRALGCGGAEAASQLAPPTPELPPPPAAGNTSVAANATLAGAPALLCSGAEWRLCEVVEHACRSDGRRARVTCAENRALRLVDGGGACAGRVEMLEHGEWGSVCDDTWDLEDAHVVCRQLGCGWAVQALPGLHFTPGRGPIHRDQVNCSGAEAYLWDCPGLPGQHYCGHKEDAGAVCSEHQSWRLTGGADRCEGQVEVHFRGVWNTVCDSEWYPSEAKVLCQSLGCGTAVERPKGLPHSLSGRMYYSCNGEELTLSNCSWRFNNSNLCSQSLAARVLCSASRSLHNLSTPEVPASVQTVTIESSVTVKIENKESRELMLL
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Predicted Molecular Mass
42.1 kDa
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Molecular Weight
Approximately 70-90 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (237 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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