CD6 - CD6 molecule Gene

Also Known as TP120

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 923

About CD6

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:60,971,680-61,020,377 (from NCBI)

This gene has 14 transcripts (splice variants), 139 orthologues and 15 paralogues. Biased expression in lymph node (RPKM 22.7), appendix (RPKM 13.7) and 9 other tissues.

Summary

This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some Other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

CD6 Products (3)

mRNA Protein Name
NM_001254750.2 NP_001241679.1 T-cell differentiation antigen CD6 isoform 2 precursor
NM_001254751.2 NP_001241680.1 T-cell differentiation antigen CD6 isoform 3 precursor
NM_006725.5 NP_006716.3 T-cell differentiation antigen CD6 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
26146185 GOA
enables lipopolysaccharide binding IDA
IDA: Inferred from direct assay
17601777 GOA
enables lipoteichoic acid binding IMP
IMP: Inferred from mutant phenotype
17601777 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24584089 GOA
Biological Process GO Annotation Evidence References Source
involved in acute inflammatory response to antigenic stimulus IDA
IDA: Inferred from direct assay
17601777 GOA
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP
IMP: Inferred from mutant phenotype
16352806 GOA
involved in immunological synapse formation IMP
IMP: Inferred from mutant phenotype
15294938 GOA
involved in lipopolysaccharide-mediated signaling pathway IDA
IDA: Inferred from direct assay
17601777 GOA
involved in positive regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
15294938 GOA
involved in positive regulation of cytokine production involved in inflammatory response IDA
IDA: Inferred from direct assay
17601777 GOA
involved in response to lipopolysaccharide IDA
IDA: Inferred from direct assay
17601777 GOA
Cellular Component GO Annotation Evidence References Source
part of T cell receptor complex IDA
IDA: Inferred from direct assay
15294938 GOA
located in immunological synapse IDA
IDA: Inferred from direct assay
15294938 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
15294938 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD6 Protein Structure

SRCR

SRCR: Scavenger receptor cysteine-rich domain (48 - 155)

SRCR

SRCR: Scavenger receptor cysteine-rich domain (164 - 260)

SRCR

SRCR: Scavenger receptor cysteine-rich domain (268 - 361)

  • 0
  • 200
  • 400
  • 600
  • 668 a.a.
Protein Preferred Names Protein Names

T-cell differentiation antigen CD6

  • CD6 antigen

CD6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CD6 P30203 LGALS3 Homo sapiens P17931
Pull Down
24945728
Intra
CD6 P30203 LGALS3 Homo sapiens P17931
ELISA
24945728
Intra
CD6 P30203 ALCAM Homo sapiens Q13740
SLCA
26146185
Intra
CD6 P30203 ALCAM Homo sapiens Q13740
Light Scattering
26146185
Intra
CD6 P30203 ALCAM Homo sapiens Q13740
GMS
26146185
Intra
CD6 P30203 ALCAM Homo sapiens Q13740
Anti Tag CoIP
33961781
Intra
CD6 P30203 acn Yersinia pestis A0A380PDG1
Y2H Pooling
20711500
Intra
CD6 P30203 CD6 Homo sapiens P30203
SLCA
26146185
Intra
CD6 P30203 LCP2 Homo sapiens Q13094
Anti Bait CoIP
24584089
Intra
CD6 P30203 Sdcbp Mus musculus O08992
Y2H Array
16034076
Intra
CD6 P30203 CD6 Homo sapiens P30203
GMS
26146185
Intra
CD6 P30203 Sdcbp Mus musculus O08992
Anti Bait CoIP
16034076
Intra
CD6 P30203 Sdcbp Mus musculus O08992
Pull Down
16034076
Intra
CD6 P30203 CD6 Homo sapiens P30203
Light Scattering
26146185
Intra
CD6 P30203 GYG1 Homo sapiens P46976
Y2H Array
21988832
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD6 Proteins

Cat. No. Product Name Accession Purity
HY-P72922 CD6 Protein, Human (HEK293, Fc) P30203 (H18-E398) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P700684 CD6 Protein, Human (HEK293, His) NP_006716.3 (H18-L402) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Inflammatory Bowel Disease 16

  • IBD16

  • Inflammatory Bowel Disease 16, Susceptibility To
Multiple Sclerosis

  • MS

  • Multiple Sclerosis, Susceptibility To

  • Disseminated Sclerosis

  • Multiple Sclerosis, Disease Progression, Modifier Of

  • Insular Sclerosis

  • Multiple Sclerosis Modifier Of Disease Progression

  • Multiple Sclerosis, Susceptibility To 1

  • Multiple Sclerosis, Susceptibility To, 1

  • Multiple Sclerosis 1

  • Generalized Multiple Sclerosis

  • Multiple Sclerosis Variant

  • Multiple Sclerosis Susceptibility To

  • Cerebrospinal Sclerosis

  • Generalised Multiple Sclerosis

  • Ms - [Multiple Sclerosis]

  • Disseminated Cerebrospinal Sclerosis

  • Disseminated Multiple Sclerosis

  • Disseminated Nervous System Myelosclerosis

  • Multiple Cerebrospinal Sclerosis

  • Multiple Combined Sclerosis

  • Multiple Sclerosis Generalised

  • Disseminated Brain Sclerosis

  • Disseminated Spinal Sclerosis

  • Insular Brain Sclerosis

  • Miliary Brain Sclerosis

  • Multiple Combined Sclerosis Of Spinal Cord

  • Multiple Ascending Sclerosis

  • Multiple Brain Sclerosis

  • Multiple Sclerosis Of Brain Stem

  • Multiple Sclerosis Of The Brain Stem

  • Multiple Sclerosis Of Cord

  • Sclérose En Plaques

  • Plaque Sclerosis

  • Multiple Sclerosis Of The Spinal Cord
Inflammatory Bowel Disease 18

  • IBD18
Diamond-Blackfan Anemia 1

  • Aase Syndrome

  • DBA1

  • Erythrogenesis Imperfecta

  • Aase-Smith Syndrome Ii

  • Dba

  • Blackfan-Diamond Syndrome

  • Bds

  • Anemia, Congenital Hypoplastic, Of Blackfan And Diamond

  • Anemia, Congenital Erythroid Hypoplastic

  • Red Cell Aplasia, Pure, Hereditary

  • Aregenerative Anemia, Chronic Congenital

  • Rps19-Related Diamond-Blackfan Anemia

  • Chronic Congenital Aregenerative Anemia

  • Congenital Erythroid Hypoplastic Anemia

  • Congenital Hypoplastic Anemia Of Blackfan And Diamond

  • Pure Hereditary Red Cell Aplasia

  • Anemia, Diamond-Blackfan, Type 1

  • Anemia, Diamond-Blackfan

  • Aase Smith Syndrome 2

  • Familial Hypoplastic Anaemia With Malformations

  • Constitutional Pure Red Cell Aplasia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99252 Itolizumab ≥99.0% Phase 3

Orthologs Information

Species Symbol Source ID
Felis catus CD6 VGNC VGNC:60635
Rattus norvegicus CD6 RGD RGD:2312
Canis familiaris CD6 VGNC VGNC:38966
Mus musculus CD6 MGD MGI:103566
Macaca mulatta CD6 VGNC VGNC:100906
Bos taurus CD6 VGNC VGNC:27041
Others CD6 NCBI