CD6 - CD6 molecule Gene

Homo sapiens

Also known as TP120

Gene ID: 923 | Gene type: protein coding

About CD6

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:60,971,680-61,020,377 (from NCBI)

This gene has 14 transcripts (splice variants), 139 orthologues and 15 paralogues. Biased expression in lymph node (RPKM 22.7), appendix (RPKM 13.7) and 9 other tissues.

Summary

This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

CD6 Products(3)

mRNA	Protein	Name
NM_001254750.2	NP_001241679.1	T-cell differentiation antigen CD6 isoform 2 precursor
NM_001254751.2	NP_001241680.1	T-cell differentiation antigen CD6 isoform 3 precursor
NM_006725.5	NP_006716.3	T-cell differentiation antigen CD6 isoform 1 precursor

CD6 Protein Structure

SRCR

0
200
400
600
668 a.a.

Protein Preferred Names

Protein Names

T-cell differentiation antigen CD6

CD6 antigen

Recombinant CD6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72922	CD6 Protein, Human (HEK293, Fc)	P30203 (H18-E398)	≥95%
HY-P700684	CD6 Protein, Human (HEK293, His)	NP_006716.3 (H18-L402)	≥95%

Related Diseases

Diseases

Alias

Inflammatory Bowel Disease 16

IBD16

Inflammatory Bowel Disease 16, Susceptibility To

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Inflammatory Bowel Disease 18

IBD18

Diamond-Blackfan Anemia 1

Aase Syndrome	DBA1
Erythrogenesis Imperfecta	Aase-Smith Syndrome Ii
Dba	Blackfan-Diamond Syndrome
Bds	Anemia, Congenital Hypoplastic, Of Blackfan And Diamond
Anemia, Congenital Erythroid Hypoplastic	Red Cell Aplasia, Pure, Hereditary
Aregenerative Anemia, Chronic Congenital	Rps19-Related Diamond-Blackfan Anemia
Chronic Congenital Aregenerative Anemia	Congenital Erythroid Hypoplastic Anemia
Congenital Hypoplastic Anemia Of Blackfan And Diamond	Pure Hereditary Red Cell Aplasia
Anemia, Diamond-Blackfan, Type 1	Anemia, Diamond-Blackfan
Aase Smith Syndrome 2	Familial Hypoplastic Anaemia With Malformations
Constitutional Pure Red Cell Aplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99252	Itolizumab		95.00%	Phase 3

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CD6	VGNC	VGNC:60635
Rattus norvegicus	CD6	RGD	RGD:2312
Canis familiaris	CD6	VGNC	VGNC:38966
Mus musculus	CD6	MGD	MGI:103566
Macaca mulatta	CD6	VGNC	VGNC:100906
Bos taurus	CD6	VGNC	VGNC:27041
Macaca fascicularis	CD6	NCBI
Susscrofa domestica	CD6	NCBI
Leporidae	CD6	NCBI
Others	CD6	NCBI