HBA

By Targets:	Amyloid-β (1) Bacterial (1) Biochemical Assay Reagents (2) Caspase (1) CMV (1) HSV (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (1) Infection (1) Inflammation/Immunology (2) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103667

2-HBA

3 Publications Verification

Caspase Cancer

2-HBA is a potent inducer of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10.

2-HBA 3 Publications Verification	Caspase	Cancer
2-HBA is a potent inducer of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10.

HY-149689

4-Ketobenzotriazine-O-CH2-COOH HBA	Biochemical Assay Reagents	Inflammation/Immunology
2-[(4-Oxo-1,2,3-benzotriazin-3-yl)oxy]acetic acid (HBA) is a hapten with a carboxyl group at the end of its spacer arm, suitable for reacting with free amine groups of proteins. 2-[(4-Oxo-1,2,3-benzotriazin-3-yl)oxy]acetic acid can be combined with carrier proteins and used in antigen design .

HY-P5693

HBA(111–142)	Bacterial CMV HSV	Infection
HBA(111-142), an antimicrobial peptide, is a C-terminal 32-mer fragment of alpha-hemoglobin. HBA(111-142) has antibacterial activity against the ESKAPE panel of pathogens. HBA(111-142) forms amyloid fibrils, and has antiviral activities. HBA(111-142) inhibits measles and herpes viruses (HSV-1, HSV-2, HCMV) .

HY-RS06024

HBA1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HBA1 Human Pre-designed siRNA Set A contains three designed siRNAs for HBA1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HBA1 Human Pre-designed siRNA Set A HBA1 Human Pre-designed siRNA Set A

HY-RS06025

HBA2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HBA2 Human Pre-designed siRNA Set A contains three designed siRNAs for HBA2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HBA2 Human Pre-designed siRNA Set A HBA2 Human Pre-designed siRNA Set A

HY-W751932

Carboxy-EG6-undecanethiol	Biochemical Assay Reagents	Others
Carboxy-EG6-undecanethiol is an alkanethiol that suitable for self-assembly a gold thin-film substrate. Carboxy-EG6-undecanethiol can selectively capture HbA1c in sample by covalent coupling of 3-aminophenyl boronic acid (3-APBA) .

HY-P1047

β-Sheet Breaker Peptide iAβ5 [Pro18, Asp21] β-Amyloid (17-21)	Amyloid-β	Neurological Disease
β-Sheet Breaker Peptide iAβ5 is a potent degrader of cerebral amyloid-beta (Abeta). Abeta deposition is associatied with the Alzheimer disease (AD), due to its related toxicity linked to its beta-sheet conformation and/or aggregation. β-Sheet Breaker Peptide iAβ5 reproducibly induces in vivo disassembly of fibrillar amyloid deposits. Thus, β-Sheet Breaker Peptide iAβ5 prevents and/or reverses neuronal shrinkage caused by Abeta, and reduces the extent of interleukin-1beta positive microglia-like cells that surround the Abeta deposits. β-Sheet Breaker Peptide iAβ5 reduces the size and/or number of cerebral amyloid plaques in AD. β-Sheet Breaker Peptide iAβ5 labeled by hydrophobic benzyl alcohol (HBA) tag, can be used for quantitative assay by showing vivid blue color under acidic conditions .

Cat. No.	Product Name

HY-L912V

MegaUni 10M Virtual Diversity Library	10,000,000 compounds
With MCE's 40,662 BBs, covering around 273 reaction types, more than 40 million molecules were generated. Compounds which comply with Ro5 criteria were selected. Inappropriate chemical structures, such as PAINS motifs and synthetically difficult accessible, were removed. Based on Morgan Fingerprint, molecular clustering analysis was carried out, and molecules close to each clustering center were extracted to form this drug-like and synthesizable diversity library. These selected molecules have 805,822 unique Bemis-Murcko Scaffolds (BMS) with diversified chemical space. This library is highly recommended for AI-based lead discovery, ultra-large virtual screening and novel lead discovery.

MegaUni 10M Virtual Diversity Library

10,000,000 compounds

With MCE's 40,662 BBs, covering around 273 reaction types, more than 40 million molecules were generated. Compounds which comply with Ro5 criteria were selected. Inappropriate chemical structures, such as PAINS motifs and synthetically difficult accessible, were removed. Based on Morgan Fingerprint, molecular clustering analysis was carried out, and molecules close to each clustering center were extracted to form this drug-like and synthesizable diversity library. These selected molecules have 805,822 unique Bemis-Murcko Scaffolds (BMS) with diversified chemical space. This library is highly recommended for AI-based lead discovery, ultra-large virtual screening and novel lead discovery.

HY-L0121V

MCE 10K Natural Product-like Compound Library	10,000 compounds
Natural products are an attractive source with varied structures that exhibit potent biological activities, and desirable pharmacological profiles. The core scaffold of a natural product can also provide a biologically validated framework upon which to display diverse functional groups. Inspired by bioactive natural products, natural product-like compounds, occupying the same chemical space, are ideally suited to explore and to facilitate understanding of biological pathways. MCE 10K Natural Product-like Compound Library consists of 10,000 natural product-like compounds. Each compound has scaffold of natural products or Tanimoto coefficient >0.6 with natural products. The natural-likeness scoring of these compounds is >-2. What’s more, compounds in the library are drug-like and readily available for re-supply, making it a powerful tool for new drug research and development. It can be widely applied in high-throughput screening (HTS) and high-content screening (HCS).

MCE 10K Natural Product-like Compound Library

10,000 compounds

Natural products are an attractive source with varied structures that exhibit potent biological activities, and desirable pharmacological profiles. The core scaffold of a natural product can also provide a biologically validated framework upon which to display diverse functional groups. Inspired by bioactive natural products, natural product-like compounds, occupying the same chemical space, are ideally suited to explore and to facilitate understanding of biological pathways.

MCE 10K Natural Product-like Compound Library consists of 10,000 natural product-like compounds. Each compound has scaffold of natural products or Tanimoto coefficient >0.6 with natural products. The natural-likeness scoring of these compounds is >-2. What’s more, compounds in the library are drug-like and readily available for re-supply, making it a powerful tool for new drug research and development. It can be widely applied in high-throughput screening (HTS) and high-content screening (HCS).

HY-L910V

MegaUni 50K Virtual Diversity Library	50,000 compounds
MegaUni 50K Virtual Diversity Library consists of 50,000 novel, synthetically accessible, lead-like compounds. With MCE's 40,662 Building Blocks, covering around 273 reaction types, more than 40 million molecules were generated. Based on Morgan Fingerprint and Tanimoto Coefficient, molecular clustering analysis was carried out, and molecules closest to each clustering center were extracted to form a drug-like and synthesizable diversity library. The selected 50,000 drug-like molecules have 46,744 unique Bemis-Murcko Scaffolds (BMS), each containing only 1-3 compounds. This diverse library is highly recommended for virtual screening and novel lead discovery.

MegaUni 50K Virtual Diversity Library

50,000 compounds

MegaUni 50K Virtual Diversity Library consists of 50,000 novel, synthetically accessible, lead-like compounds. With MCE's 40,662 Building Blocks, covering around 273 reaction types, more than 40 million molecules were generated. Based on Morgan Fingerprint and Tanimoto Coefficient, molecular clustering analysis was carried out, and molecules closest to each clustering center were extracted to form a drug-like and synthesizable diversity library. The selected 50,000 drug-like molecules have 46,744 unique Bemis-Murcko Scaffolds (BMS), each containing only 1-3 compounds. This diverse library is highly recommended for virtual screening and novel lead discovery.

HY-L0093V

Chemspace Scaffold derived set	10,119 compounds
Diversity-based screening continues to be a vital tool for drug discovery. Efficiency and productivity can be improved by using screening libraries that offer maximum diversity whilst retaining drug-like properties. Chemspace Scaffold derived set composes 10,119 compounds, which including 3,373 scaffolds, 3 compounds per each. This library has exceptional coverage of drug-like chemical space.

HY-L0104V

UORSY New Generation Screening Library	1,900,000 compounds
UORSY New Generation Screening Library contains about 1,900,000 compounds. The library is a revolutionary collection of lead-like molecules with outstanding structural quality and diversity—New Generation Screening Library (NGSL). Its core is decorated with interesting building blocks, including important medicinal fragments such as peptide bonds, amino groups and hydroxyl groups. and designed for discovery of new Voltage-gated calcium channel blockers.

UORSY New Generation Screening Library

1,900,000 compounds

UORSY New Generation Screening Library contains about 1,900,000 compounds. The library is a revolutionary collection of lead-like molecules with outstanding structural quality and diversity—New Generation Screening Library (NGSL). Its core is decorated with interesting building blocks, including important medicinal fragments such as peptide bonds, amino groups and hydroxyl groups. and designed for discovery of new Voltage-gated calcium channel blockers.

Cat. No.	Product Name	Type

HY-W751932

Carboxy-EG6-undecanethiol	Biochemical Assay Reagents
Carboxy-EG6-undecanethiol is an alkanethiol that suitable for self-assembly a gold thin-film substrate. Carboxy-EG6-undecanethiol can selectively capture HbA1c in sample by covalent coupling of 3-aminophenyl boronic acid (3-APBA) .

Cat. No.	Product Name	Target	Research Area

HY-P1047

β-Sheet Breaker Peptide iAβ5 [Pro18, Asp21] β-Amyloid (17-21)	Amyloid-β	Neurological Disease
β-Sheet Breaker Peptide iAβ5 is a potent degrader of cerebral amyloid-beta (Abeta). Abeta deposition is associatied with the Alzheimer disease (AD), due to its related toxicity linked to its beta-sheet conformation and/or aggregation. β-Sheet Breaker Peptide iAβ5 reproducibly induces in vivo disassembly of fibrillar amyloid deposits. Thus, β-Sheet Breaker Peptide iAβ5 prevents and/or reverses neuronal shrinkage caused by Abeta, and reduces the extent of interleukin-1beta positive microglia-like cells that surround the Abeta deposits. β-Sheet Breaker Peptide iAβ5 reduces the size and/or number of cerebral amyloid plaques in AD. β-Sheet Breaker Peptide iAβ5 labeled by hydrophobic benzyl alcohol (HBA) tag, can be used for quantitative assay by showing vivid blue color under acidic conditions .

HY-P5693

HBA(111–142)	Bacterial CMV HSV	Infection
HBA(111-142), an antimicrobial peptide, is a C-terminal 32-mer fragment of alpha-hemoglobin. HBA(111-142) has antibacterial activity against the ESKAPE panel of pathogens. HBA(111-142) forms amyloid fibrils, and has antiviral activities. HBA(111-142) inhibits measles and herpes viruses (HSV-1, HSV-2, HCMV) .

HY-P4664

VHLTP

Peptides Inflammation/Immunology

VHLTP is the N-terminal pentapeptide of human hemoglobin beta. VHLTP binds to cell membranes and serves as a ligand for anti-HbA1c antibodies .

VHLTP	Peptides	Inflammation/Immunology
VHLTP is the N-terminal pentapeptide of human hemoglobin beta. VHLTP binds to cell membranes and serves as a ligand for anti-HbA1c antibodies .

Species:	Human (3)
Tag:	His (2) Fc (1)
Source:	HEK293 (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P70397

	*Hemoglobin subunit alpha/HBA1 Protein, Human (His)* rHuHemoglobin subunit alpha/HBA1, His; Hemoglobin subunit alpha; Alpha-globin; Hemoglobin alpha chain; HBA1; HBH; HBA-T3	Human	E. coli
	Hemoglobin subunit alpha/HBA1 protein plays a crucial role in oxygen transport and gas exchange within the human body. It also acts as a regulator in the cannabinoid receptor pathway by interacting with hemopressin, a CNR1 antagonist. This dual functionality highlights the multifaceted significance of HBA1, contributing not only to vital oxygen transport but also to the modulation of cannabinoid receptor-mediated processes. Hemoglobin subunit alpha/HBA1 Protein, Human (His) is the recombinant human-derived Hemoglobin subunit alpha/HBA1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of Hemoglobin subunit alpha/HBA1 Protein, Human (His) is 142 a.a., with molecular weight of ~21 kDa.

HY-P701277

	FITC-Labeled CD99 Protein, Human (HEK293, Fc) CD99; HBA71; MIC2; MIC2X; MIC2Y; MSK5X; 12E7	Human	HEK293
	The CD99 protein is involved in the important T cell adhesion process and helps red blood cells spontaneously form rosettes. It also contributes to the later stages of leukocyte extravasation, helping leukocytes to overcome the endothelial basement membrane during the immune response. FITC-Labeled CD99 Protein, Human (HEK293, Fc) is the recombinant human-derived FITC-Labeled CD99 protein, expressed by HEK293 , with Fc labeled tag. The total length of FITC-Labeled CD99 Protein, Human (HEK293, Fc) is 100 a.a., with molecular weight of 45-55 kDa.

HY-P77623

	CD99 Protein, Human (HEK293, His) 12E7; E2 antigen; MIC2; MIC2X; MIC2Y; CD99; HBA71; MSK5X; 12E7; 1110061M03Rik; 2410026K10Rik; D4; pilr-1; Pilr-l; CD99 molecule	Human	HEK293
	The CD99 protein is involved in the important T cell adhesion process and helps red blood cells spontaneously form rosettes. It also contributes to the later stages of leukocyte extravasation, helping leukocytes to overcome the endothelial basement membrane during the immune response. CD99 Protein, Human (HEK293, His) is the recombinant human-derived CD99 protein, expressed by HEK293 , with N-His labeled tag. The total length of CD99 Protein, Human (HEK293, His) is 100 a.a., with molecular weight of 20-25 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P81428

Hemoglobin subunit alpha Antibody (YA1173)

HBA1; HBA2; Hemoglobin subunit alpha; Alpha-globin; Hemoglobin alpha chain; Hemopressin
IHC-P Human

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Screening Libraries

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