Hemoglobin subunit alpha/HBA1 Protein, Human (His)

Hemoglobin subunit alpha/HBA1 protein plays a crucial role in oxygen transport and gas exchange within the human body. It also acts as a regulator in the cannabinoid receptor pathway by interacting with hemopressin, a CNR1 antagonist. This dual functionality highlights the multifaceted significance of HBA1, contributing not only to vital oxygen transport but also to the modulation of cannabinoid receptor-mediated processes. Hemoglobin subunit alpha/HBA1 Protein, Human (His) is the recombinant human-derived Hemoglobin subunit alpha/HBA1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of Hemoglobin subunit alpha/HBA1 Protein, Human (His) is 142 a.a., with molecular weight of ~21 kDa.

Hemoglobin subunit alpha/HBA1 protein plays a crucial role in oxygen transport from the lung to various peripheral tissues, serving as an essential component in the intricate process of gas exchange within the human body. Additionally, it interacts with hemopressin, acting as an antagonist peptide of the cannabinoid receptor CNR1. Through its binding, hemopressin efficiently blocks CNR1 and subsequent signaling, revealing a regulatory role in the cannabinoid receptor pathway. This dual functionality underscores the multifaceted significance of Hemoglobin subunit alpha/HBA1, contributing not only to vital oxygen transport but also to the modulation of cannabinoid receptor-mediated processes.

Data is not available.

Human

E. coli

N-6*His

P69905 (M1-R142)

3039  [NCBI]

MVLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR

Approximately 21 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, 1 mM EDTA, pH 8.0 or 50 mM Tris-HCL, 300 mM NaCL, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.