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Results for "

Hemslecin A

" in MedChemExpress (MCE) Product Catalog:

3

Inhibitors & Agonists

3

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N1988
    Cucurbitacin IIa
    1 Publications Verification

    Hemslecin A

    		 Survivin Apoptosis EGFR Caspase p38 MAPK Autophagy MEK Raf ERK STAT CaMK Inflammation/Immunology Cancer
    Cucurbitacin IIa (Hemslecin A) is an orally active, blood-brain barrier-permeable EGFR inhibitor with an IC50 of 1.455 nM against human EGFR. Cucurbitacin IIa induces caspase-3-dependent apoptosis, downregulates survivin expression, enhances autophagy levels, disrupts the actin cytoskeleton via actin aggregation, arrests the cell cycle at the G2/M phase, and exerts anti-inflammatory activity by inhibiting the EGFR-MAPK signaling pathway. Cucurbitacin IIa can be used in the research of inflammation-related diseases, depression, and cancers such as non-small cell lung cancer .
    Cucurbitacin IIa
  • HY-N1988R
    Cucurbitacin IIa (Standard)

    Hemslecin A (Standard)

    		 Reference Standards Apoptosis EGFR Autophagy MEK Caspase ERK STAT Survivin Raf p38 MAPK CaMK Inflammation/Immunology Cancer
    Cucurbitacin IIa (Hemslecin A) (Standard) is the analytical standard for Cucurbitacin IIa (HY-N1988). This product is used for research and analytical applications. Cucurbitacin IIa is an orally active, blood-brain barrier-penetrating EGFR inhibitor with an IC50 of 1.455 nM for human EGFR. Cucurbitacin IIa induces caspase-3 dependent cell apoptosis, downregulates survivin expression, enhances autophagy levels, disrupts the actin cytoskeleton through actin aggregation, blocks the cell cycle at the G2/M phase, and inhibits the EGFR-MAPK signaling pathway to exert anti-inflammatory activity. Cucurbitacin IIa can be used in research on inflammatory-related diseases, depression, and non-small cell lung cancer and other cancers.
    Cucurbitacin IIa (Standard)
  • HY-N12552
    Cucurbitacin IIa 2-O-β-D-glucoside

    Hemslecin A 2-O-β-d-glucopyranoside

    		 Others Infection
    Cucurbitacin IIa 2-O-β-D-glucoside is a glycoside cucurbitacin isolated from the genus Hemsleya (Cucurbitaceae). Extracts of Hemsleya have the potential to be used in research on bronchitis, bacillary dysentery, and tuberculosis .
    Cucurbitacin IIa 2-O-β-D-glucoside

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