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Heparanase 1, Human

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Endogenous Metabolite (1) FGFR (1) Glycosidase (1) VEGFR (1)
By Research Areas:	Cancer (1) Inflammation/Immunology (1)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-E70337

**Heparanase 1, Human**	Endogenous Metabolite	Others
Heparanase 1, Human is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible ^[1].

HY-P992234

Anti-Heparanase Antibody	Glycosidase	Inflammation/Immunology
Anti-Heparanase Antibody is a monoclonal antibody that targets heparanase. It can be used in ELISA, FACS, and functional assays. For isotype controls of anti-heparanase antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-19891

PG545	FGFR VEGFR	Cancer
PG545 is a *heparanase* inhibitor and an FGF/VEGF inhibitor, with a K_i value of 6.1 nM against human heparanase, and K_d values of 8 nM, 390 nM, and 28.9 nM against human FGF-1, FGF-2, and VEGF, respectively. PG545 inhibits angiogenesis, tumor growth, and metastasis. PG545 is applicable in research related to melanoma and colorectal cancer ^[1].

Cat. No.	Product Name	Target	Research Area	Image

HY-P992234

Anti-Heparanase Antibody	Glycosidase	Inflammation/Immunology
Anti-Heparanase Antibody is a monoclonal antibody that targets heparanase. It can be used in ELISA, FACS, and functional assays. For isotype controls of anti-heparanase antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P79276

	Heparanase/HPSE Protein, Human (CHO, His) Heparanase; Endo-glucoronidase; Heparanase-1; Hpa1; HEP, HPA, HPA1, HPR1, HPSE1, HSE1; HPSE	Human	CHO
	Heparanase (HPSE) functions as an endoglycosidase, playing a crucial role in the cleavage of heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. It is implicated in various cellular processes, including facilitating cell migration associated with metastasis, wound healing, and inflammation. Heparanase also plays a role in cell adhesion to the ECM, independent of its enzymatic activity, and induces AKT1/PKB phosphorylation, thereby increasing cell mobility and invasion. Additionally, Heparanase is involved in the regulation of osteogenesis, promotes angiogenesis through up-regulation of SRC-mediated activation of VEGF, and is implicated in hair follicle inner root sheath differentiation and hair homeostasis. Heparanase/HPSE Protein, Human (CHO, His) is the recombinant human-derived Heparanase/HPSE protein, expressed by CHO , with N-6*His labeled tag.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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