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Results for "

IDN

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-10396
    Emricasan
    50+ Cited Publications

    PF 03491390; IDN-6556

    		 Caspase Flavivirus Infection Neurological Disease Cancer
    Emricasan (PF 03491390) is an orally active and irreversible pan-caspase inhibitor. Emricasan inhibits Zika virus (ZIKV)-induced increases in caspase-3 activity and protected human cortical neural progenitors .
    Emricasan
  • HY-120257
    IDN-1965

    		Caspase Apoptosis Cardiovascular Disease
    IDN-1965 is an irreversible, broad-spectrum caspase inhibitor. IDN-1965 prevents downstream apoptotic events (such as DNase activation) and significantly delays cytochrome c release by inhibiting caspase activity. IDN-1965 significantly delayed death in mice with cardiomyocyte apoptosis. IDN-1965 completely prevents left ventricular dilation, systolic dysfunction, and fibrosis in mice with dilated cardiomyopathy. IDN-1965 can be used to study apoptosis-related diseases such as heart failure and the mechanisms of apoptosis initiation .
    IDN-1965
  • HY-10396R
    Emricasan (Standard)

    PF 03491390 (Standard); IDN-6556 (Standard)

    		 Reference Standards Caspase Flavivirus Infection Neurological Disease Cancer
    Emricasan (Standard) is the analytical standard of Emricasan. This product is intended for research and analytical applications. Emricasan (PF 03491390) is an orally active and irreversible pan-caspase inhibitor. Emricasan inhibits Zika virus (ZIKV)-induced increases in caspase-3 activity and protected human cortical neural progenitors .
    Emricasan (Standard)
  • HY-10396A
    (2R,3S)-Emricasan

    (2R,3S)-PF 03491390; (2R,3S)-IDN-6556

    		 Caspase Flavivirus Infection Neurological Disease Cancer
    (2R,3S)-Emricasan ((2R,3S)-PF 03491390) is an isomer of Emricasan (HY-10396). Emricasan is an orally active and irreversible pan-caspase inhibitor. Emricasan inhibits Zika virus (ZIKV)-induced increases in caspase-3 activity and protected human cortical neural progenitors .
    (2R,3S)-Emricasan
  • HY-16371
    Ortataxel

    IDN 5109; BAY 59-8862

    		 Microtubule/Tubulin Cancer
    Ortataxel (IDN 5109; BAY 59-8862) is a derivative of Paclitaxel (HY-B0015). Ortataxel exhibits activity against multiple drug-sensitive and resistant cancer cell lines .
    Ortataxel
  • HY-105943
    IDN-5404

    		Drug Derivative Cancer
    IDN-5404 is a thio Colchicine (HY-16569) analogue. IDN-5404 can be used for cancer research .
    IDN-5404
  • HY-111096
    IDN-7314

    		Caspase Cardiovascular Disease Metabolic Disease
    IDN-7314 is a pan-Caspase inhibitor with an IC50 of 0.2-7 nM against all tested Caspases. IDN-7314 abrogates Jo2-induced caspase-3/7 activity. IDN-7314 reduces the procoagulant activity of tissue factor in hepatocytes. IDN-7314 is applicable to research related to chemically induced hepatitis, fulminant liver failure and apoptotic liver injury .
    IDN-7314

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