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Cat. No.: HY-16371

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Ortataxel

(Synonyms: IDN 5109; BAY 59-8862)

Ortataxel (IDN 5109; BAY 59-8862) is a derivative of Paclitaxel (HY-B0015). Ortataxel exhibits activity against multiple drug-sensitive and resistant cancer cell lines.

For research use only. We do not sell to patients.

CAS No.: 186348-23-2
Formula: C₄₄H₅₇NO₁₇
Molecular Weight:871.92

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (281 KB)

Ortataxel Chemical Structure

CAS No.: 186348-23-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- Clinical Trial
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Ortataxel (IDN 5109; BAY 59-8862) is a derivative of Paclitaxel (HY-B0015). Ortataxel exhibits activity against multiple drug-sensitive and resistant cancer cell lines^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	3.6 nM Compound: Ortataxel	In vitro cytotoxicity against A2780CIS cell line In vitro cytotoxicity against A2780CIS cell line	[PMID: 14584931]
A2780	IC₅₀	4.8 nM Compound: Ortataxel	In vitro cytotoxicity against A2780 cell line In vitro cytotoxicity against A2780 cell line	[PMID: 14584931]
A2780	IC₅₀	56 nM Compound: Ortataxel	In vitro cytotoxicity against A2780TAX cell line In vitro cytotoxicity against A2780TAX cell line	[PMID: 14584931]
A2780	IC₅₀	63 nM Compound: Ortataxel	In vitro cytotoxicity against A2780ADR cell line In vitro cytotoxicity against A2780ADR cell line	[PMID: 14584931]
MCF7	IC₅₀	1.1 nM Compound: Ortataxel	In vitro cytotoxicity against MCF-7 cell line In vitro cytotoxicity against MCF-7 cell line	[PMID: 14584931]
MCF7	IC₅₀	1.6 nM Compound: 3	Cytotoxic potency in MCF7 human mammary carcinoma cell line after 72 hr exposure by SRB test Cytotoxic potency in MCF7 human mammary carcinoma cell line after 72 hr exposure by SRB test	[PMID: 16183281]
MCF7-DOX	IC₅₀	32 nM Compound: 3	Cytotoxic potency in doxorubicin resistant MCF7 cell line after 72 hr exposure by SRB test Cytotoxic potency in doxorubicin resistant MCF7 cell line after 72 hr exposure by SRB test	[PMID: 16183281]
MCF7R	IC₅₀	33 nM Compound: Ortataxel	Potency differential in resistant to that of sensitive MCF7-R cell line Potency differential in resistant to that of sensitive MCF7-R cell line	[PMID: 14584931]
MCF7R	IC₅₀	36 nM Compound: Ortataxel	In vitro cytotoxicity against MCF7-R cell line In vitro cytotoxicity against MCF7-R cell line	[PMID: 14584931]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 186348-23-2
Molecular Weight 871.92
Formula C₄₄H₅₇NO₁₇
SMILES

CC(C)C[C@H](NC(OC(C)(C)C)=O)[C@@H](O)C(O[C@@H]([C@]1([H])OC(O[C@@]12[C@@H](OC(C3=CC=CC=C3)=O)[C@@]4([H])[C@@]5(C)[C@@H](O)C[C@]6([H])[C@@]4(OC(C)=O)CO6)=O)C(C)=C(C2(C)C)[C@@H](OC(C)=O)C5=O)=O
Synonyms

IDN 5109; BAY 59-8862
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xiang F, et al., Structure-activity relationship of taxol inferring from docking taxol analogues to microtubule binding site. Z Naturforsch C J Biosci. 2009 Jul-Aug;64(7-8):551-6. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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