Ortataxel
Ortataxel (IDN 5109; BAY 59-8862) is a derivative of Paclitaxel (HY-B0015). Ortataxel exhibits activity against multiple drug-sensitive and resistant cancer cell lines.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 186348-23-2
- Fòrmula: C44H57NO17
- Peso molecular:871.92
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
3.6 nM
Compound: Ortataxel
|
In vitro cytotoxicity against A2780CIS cell line
In vitro cytotoxicity against A2780CIS cell line
|
[PMID: 14584931] |
| A2780 | IC50 |
4.8 nM
Compound: Ortataxel
|
In vitro cytotoxicity against A2780 cell line
In vitro cytotoxicity against A2780 cell line
|
[PMID: 14584931] |
| A2780 | IC50 |
56 nM
Compound: Ortataxel
|
In vitro cytotoxicity against A2780TAX cell line
In vitro cytotoxicity against A2780TAX cell line
|
[PMID: 14584931] |
| A2780 | IC50 |
63 nM
Compound: Ortataxel
|
In vitro cytotoxicity against A2780ADR cell line
In vitro cytotoxicity against A2780ADR cell line
|
[PMID: 14584931] |
| MCF7 | IC50 |
1.1 nM
Compound: Ortataxel
|
In vitro cytotoxicity against MCF-7 cell line
In vitro cytotoxicity against MCF-7 cell line
|
[PMID: 14584931] |
| MCF7 | IC50 |
1.6 nM
Compound: 3
|
Cytotoxic potency in MCF7 human mammary carcinoma cell line after 72 hr exposure by SRB test
Cytotoxic potency in MCF7 human mammary carcinoma cell line after 72 hr exposure by SRB test
|
[PMID: 16183281] |
| MCF7-DOX | IC50 |
32 nM
Compound: 3
|
Cytotoxic potency in doxorubicin resistant MCF7 cell line after 72 hr exposure by SRB test
Cytotoxic potency in doxorubicin resistant MCF7 cell line after 72 hr exposure by SRB test
|
[PMID: 16183281] |
| MCF7R | IC50 |
33 nM
Compound: Ortataxel
|
Potency differential in resistant to that of sensitive MCF7-R cell line
Potency differential in resistant to that of sensitive MCF7-R cell line
|
[PMID: 14584931] |
| MCF7R | IC50 |
36 nM
Compound: Ortataxel
|
In vitro cytotoxicity against MCF7-R cell line
In vitro cytotoxicity against MCF7-R cell line
|
[PMID: 14584931] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
No. CAS 186348-23-2
-
Peso molecular 871.92
-
Fòrmula C44H57NO17
-
SMILES
CC(C)C[C@H](NC(OC(C)(C)C)=O)[C@@H](O)C(O[C@@H]([C@]1([H])OC(O[C@@]12[C@@H](OC(C3=CC=CC=C3)=O)[C@@]4([H])[C@@]5(C)[C@@H](O)C[C@]6([H])[C@@]4(OC(C)=O)CO6)=O)C(C)=C(C2(C)C)[C@@H](OC(C)=O)C5=O)=O
-
Synonyms
IDN 5109; BAY 59-8862
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ortataxel Related Classifications
HY-16371 Related Classifications
Powered by Bioz