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Results for "

IgG4κ

" in MedChemExpress (MCE) Product Catalog:

13

Inhibitors & Agonists

17

Inhibitory Antibodies

Cat. No. Product Name Target Research Area
  • HY-P99003
    Human IgG4 kappa, Isotype Control
    1 Publications Verification

    		 Inhibitory Antibodies Inflammation/Immunology
    Human IgG4 kappa, Isotype Control, a human-mouse chimeric monoclonal antibody, is an isotype control for human IgG4κ antibody.
  • HY-P99106
    Acrixolimab

    		PD-1/PD-L1 Cancer
    Acrixolimab a humanized IgG4-κ antibody, targeting to PD-1 .
  • HY-P990071
    Fepixnebart

    		Inhibitory Antibodies Cancer
    Fepixnebart is a humanized IgG4κ antibody targeting TGF-alpha (TGFA).
  • HY-P99884
    Sasanlimab

    PF-06801591

    		 PD-1/PD-L1 Others
    Sasanlimab (PF-06801591) is a humanized IgG4-κ antibody targeting PD-1. Mainly expressed by CHO (Chinese Hamster Ovary) cells .
  • HY-P990062
    Freneslerbart

    		Inhibitory Antibodies Others
    Freneslerbart is an IgG4κ antibody targeting Felcat allergen 1. Felcat allergen 1 is an allergen protein .
  • HY-P990063
    Mevonlerbart

    		Inhibitory Antibodies Others
    Mevonlerbart is an IgG4κ antibody targeting human Felcat allergen 1. Felcat allergen 1 is an allergen protein.
  • HY-P99966
    Narlumosbart

    		RANKL/RANK Cancer
    Narlumosbart (JMT103) is an IgG4κ antibody targeting receptor activator of nuclear factor-κB ligand (RANKL) .
  • HY-P99748
    Nadecnemab

    		TGF-β Receptor Inflammation/Immunology
    Nadecnemab is an IgG4κ antibody targeting to GFRA3, glial cell derived neurotrophic factor family receptor alpha 3. Nadecnemab can be used for research of osteoarthritis of the knee/pain .
  • HY-P99971
    Gemtuzumab

    		ADC Antibody Cancer
    Gemtuzumab is a monoclonal IgG4-κ antibody targeting CD33 antigen, which present on leukemic myeloblasts of acute myeloid leukemia (AML). Gemtuzumab can be used for synthesis of antibody-drug conjugate (ADC), Gemtuzumab ozogamicin (HY-109539). Gemtuzumab ozogamicin consists of a cytotoxic derivative of Calicheamicin (a cytotoxic antibiotic), and a monoclonal antibody. Gemtuzumab ozogamicin can be used for the research of acute myeloid leukemia .
  • HY-P99299
    Lexatumumab

    HGS-ETR 2; ETR2-ST01

    		 Apoptosis Cancer
    Lexatumumab (HGS-ETR 2) is a human agonistic TRAIL receptor 2 (TRAIL-R2, DR5, APO-2) IgG4κ type monoclonal antibody. Lexatumumab induces apoptosis in malignant mesothelioma. Lexatumumab can be used for malignant pleural mesothelioma (MPM) research .
  • HY-P99668
    Iparomlimab

    		PD-1/PD-L1 Cancer
    Iparomlimab is an anti-human PD-1/CD279/PDCD1 IgG4κ antibody. Iparomlimab also targets to human monoclonal PSB103 γ4-chain, disulfided with human monoclonal PSB103 κ-chain to form a dimer. Iparomlimab can be used for Oncology research .
  • HY-P9971
    Camrelizumab
    1 Publications Verification

    SHR-1210

    		 PD-1/PD-L1 Cancer
    Camrelizumab (SHR-1210) is a potent humanied high-affinity IgG4-κ monoclonal antibody (mAb) to PD-1. Camrelizumab binds PD-1 at a high affinity of 3 nM and inhibits the binding interaction of PD-1 and PD-L1 with an IC50 of 0.70 nM. Camrelizumab acts as anti-PD-1/PD-L1 agent and can be used for cancer research, including NSCLC, ESCC, Hodgkin lymphoma, and advanced HCC et,al .
  • HY-P99499
    Cetrelimab

    JNJ 63723283; JNJ 3283

    		 PD-1/PD-L1 Interleukin Related TNF Receptor Cancer
    Cetrelimab (JNJ 63723283; JNJ 3283) is a human IgG4κ mAb targeting PD-1. Cetrelimab binds PD-1 (Kd=1.72 nM, HEK293) to block the interaction of PD-1 with PD-L1 and PD-L2 (IC50s=111.7 ng/mL and 138.6 ng/mL, respectively). Cetrelimab stimulates peripheral T cells, increases IFN-γ, IL-2, TNF-α level and inhibits tumor growth in vivo .
  • HY-P99573
    Tebotelimab

    MGD-013

    		 LAG-3 Inflammation/Immunology Cancer
    Tebotelimab (MGD-013) is a humanized IgG4κ bispecific PD-1/LAG-3 dual-affinity re-targeting (DART) antibody. Tebotelimab binds cell-surface expressed PD-1 and LAG-3 with EC50s of 1.65 nM and 0.41 nM in NS0 cells, respectively. Tebotelimab blocks PD-1/PD-L1, PD-1/PD-L2 and LAG-3/HLA (MHC-II) interactions and PD-1 signaling. Tebotelimab restores exhausted T-cell responses and and enhances antitumour immunity .
  • HY-P990072
    Lipustobart

    		PD-1/PD-L1 Cancer
    Lipustobart is an IgG4-kappa, anti-PDCD1 (programmed cell death 1, PD1, PD-1, CD279) humanized monoclonal antibody. Lipustobart shows immunostimulant and antineoplastic activity .
  • HY-P990070
    Zigakibart

    BION-1301

    		 TNF Receptor Inflammation/Immunology
    Zigakibart (BION-1301) is an IgG4-kappa, anti-TNFSF13 (tumor necrosis factor (TNF) superfamily member 13, APRIL, CD256) humanized monoclonal antibody. Zigakibart shows anti-inflammatory activity .
  • HY-P99264
    Inotuzumab

    Humanized Anti-CD22 Recombinant Antibody

    		 ADC Antibody CD22 Cancer
    Inotuzumab (Humanized Anti-CD22 Recombinant Antibody) is a humanized IgG4, κ antibody that targets human CD22. Inotuzumab can be linked to a toxic agent ozogamicin as an antibody-drug conjugate (ADC). Inotuzumab can be used for the research of acute lymphoblastic leukemia and non-Hodgkin lymphoma .

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