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Results for "

Ikb-α

" in MedChemExpress (MCE) Product Catalog:

3

Inhibitors & Agonists

4

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-153188
    JNJ-1013

    		Apoptosis IRAK Cancer
    JNJ-1013 is a potent and selective IRAK1 degrader with an IC50s of 72, 443, 1071 nM for IRAK1, IRAK4, VHL FP respectively. JNJ-1013 induces Apoptosis and increases the expression of cleavaged PARP. JNJ-1013 decreases the expression IRAK1, p-IKBα, pSTAT3(Tyr705) .
    JNJ-1013
  • HY-151966
    TD1092

    		PROTACs IAP Caspase Cancer
    TD1092 is a pan-IAP degrader, degrades cIAP1, cIAP2, and XIAP. TD1092 activates Caspase 3/7, and promotes cancer cells apoptosis via IAP degradation. TD1092 inhibits TNFα mediated NF-κB pathway and reduces the phosphorylation of IKK, IkBα, p65, and p38. TD1092 can act as PROTAC, and is used for cancer research .
    TD1092
  • HY-147906
    Anticancer agent 71

    		Apoptosis PARP Cancer
    Anticancer agent 71 (Compound 4b) is a potent anticancer agent and induces apoptosis. Anticancer agent 71 arrests cell cycle at G2/M phase and induces apoptosis through upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression levels. Anticancer agent 71 shows antiproliferative activity .
    Anticancer agent 71

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