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Results for "

Isoquinoline+derivatives

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-114814A
    (+)-ORM-10921 free base

    		Adrenergic Receptor Others
    (+)-ORM-10921 Free base is a compound that exhibits significant biological activity, particularly in the context of chemical synthesis studies and the preparation of pyrido [1,2-b] isoquinoline derivatives. (+)-ORM-10921 Free base is utilized as an active reagent in multi-component reactions involving alkynes and isoquinolinium ylides. (+)-ORM-10921 Free base plays a crucial role in the advancement of synthetic organic chemistry by enabling the formation of complex molecular structures.
    (+)-ORM-10921 free base
  • HY-162962
    IDO1/TDO-IN-7

    		Indoleamine 2,3-Dioxygenase (IDO) Cancer
    IDO1/TDO-IN-7 (Compound 43b), an isoquinoline derivative, is a potent dual IDO1/TDO inhibitor, with IC50s of 0.31 μM and 0.08 μM, respectively. IDO1/TDO-IN-7 displays acceptable pharmacokinetic profiles and potent antitumor efficacy with low toxicity in B16-F10 tumor model .
    IDO1/TDO-IN-7
  • HY-168623
    EGFR-IN-134

    		EGFR Apoptosis Necroptosis Bcl-2 Family Caspase MDM-2/p53 Cancer
    EGFR-IN-134 (compound 3f), a triazolo[3,4-a]isoquinoline derivative, is a potent EGFR inhibitor with an IC50 of 0.023 µM. EGFR-IN-134 induces apoptosis and necrosis. EGFR-IN-134 initiates cell cycle arrest at the G2/M and pre-G1 phases, downregulates anti-apoptotic protein Bcl2 and upregulates pro-apoptotic proteins: p53, Bax, and caspases 3, 8, and 9. EGFR-IN-134 shows antiproliferative and anticancer activity .
    EGFR-IN-134
  • HY-181745
    Pks13-IN-3

    		Bacterial Infection
    Pks13-IN-3 is a furo[2,3-b]isoquinoline derivative and Pks13 inhibitor with an IC50 of 1.12 μM. Pks13-IN-3 reduces inhibition of the hERG ion channel. Pks13-IN-3 can be used for the research of tuberculosis .
    Pks13-IN-3

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