2. Anti-infection
  3. Bacterial
  4. Pks13-IN-3

Pks13-IN-3 is a furo[2,3-b]isoquinoline derivative and Pks13 inhibitor with an IC50 of 1.12 μM. Pks13-IN-3 reduces inhibition of the hERG ion channel. Pks13-IN-3 can be used for the research of tuberculosis.

For research use only. We do not sell to patients.

Pks13-IN-3

Pks13-IN-3 Chemical Structure

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Pks13-IN-3 Related Antibodies

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Description

Pks13-IN-3 is a furo[2,3-b]isoquinoline derivative and Pks13 inhibitor with an IC50 of 1.12 μM. Pks13-IN-3 reduces inhibition of the hERG ion channel. Pks13-IN-3 can be used for the research of tuberculosis[1].

In Vitro

Pks13-IN-3 (B23) potently inhibits Pks13-TE with an IC50 of 1.12 μM[1].
Pks13-IN-3 has reduced hERG channel inhibition, with an IC50 greater than 10 μM in HEK293 cells[1].
Pks13-IN-3 has a favorable safety profile, with CC50 values greater than 100 μM in HepG2 and Vero cells, and greater than 50 μM in 293T cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pks13-IN-3 Related Antibodies
Molecular Weight

403.38

Formula

C23H17NO6
SMILES

O=C1C2=C(OC3=C2C(CN1CC4=CC=CC(O)=C4O)=C(C=C3)O)C5=CC=C(C=C5)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Pks13-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pks13-IN-3BacterialMycobacterium tuberculosisVero cellsPks13tuberculosisHEK293 cellshERG ion channelHepG2 cells293 T cellsPks13-TEInhibitorinhibitorinhibit

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