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Results for "

LRH-1

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Biochemical Assay Reagents

1

Peptides

1

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-135589
    7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene

    		Others Cancer
    7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene is a liver receptor homolog-1 (LRH-1) antagonist with an IC50 of 3.1 μM [1].
    7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene
  • HY-131445A
    SS-RJW100

    		Others Metabolic Disease Inflammation/Immunology
    SS-RJW100 is a enantiomer of RJW100, which is a racemic agonist of nuclear receptor liver receptor homolog 1 (LRH-1) and steroidogenic factor 1 (SF-1). SS-RJW100 promotes recruitment of coregulator protein fragments in vitro, recruits the transcriptional intermediary factor 2 (Tif2) coactivator to LRH-1. SS-RJW100 diminishes LRH-1 allosteric activation networks, shows poor thermal stability [1] .
    SS-RJW100
  • HY-131445B
    RR-RJW100

    		Others Metabolic Disease
    RR-RJW100, the enantiomer of RJW100, is an nuclear receptor liver receptor homolog 1 (LRH-1) and steroidogenic factor 1 (SF-1) agonist. RJW100 can be synthesized as two enantiomers, RR-RJW100 and SS-RJW100, with RR-RJW100 shown to be the more potent LRH-1 agonist. RR-RJW100 is involved in the regulation of metabolic homeostasis and is used in studies of diabetes, liver disease and inflammatory bowel disease [1] .
    RR-RJW100
  • HY-115613
    ML-180

    SR1848

    		 Others Cancer
    ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist with an IC50 of 3.7 µM. ML-180 is inactive for steroidogenic factor-1 (SF-1; NR5A1; IC50>10 µM). ML-180 has the potential for LRH-1-dependent cancers [1] .
    ML-180
  • HY-147105
    LRH-1 modulator-1

    		Others Inflammation/Immunology
    LRH-1 modulator-1 (compound 6N) is a potent LRH-1 (liver receptor homolog-1) modulator/agonist. LRH-1 modulator-1 shows anti-inflammatory effects in intestinal organoids. LRH-1 modulator-1 induces anti-inflammatory cytokine IL-10, and reduces inflammatory cytokine IL-1b and TNFa [1].
    <em>LRH-1</em> modulator-<em>1</em>
  • HY-131445
    RJW100

    		MicroRNA Endocrinology Cancer
    RJW100 is a potent liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1) agonist with pEC50s of 6.6 and 7.5, respectively [1]. RJW100 also causes strong activation of the miR-200c (miRNA-200c, microRNA-200c) promoter .
    RJW100
  • HY-107737
    DLPC
    1 Publications Verification

    1,2-Dilauroyl-sn-glycero-3-phosphocholine

    		 Liposome Metabolic Disease
    DLPC (1,2-Dilauroyl-sn-glycero-3-phosphocholine) is an LRH-1 agonist ligand. DLPC is a phospholipid for biological study [1] .
    DLPC
  • HY-110329
    ML179

    		Others Cancer
    ML179 (SR-1309) is a inverse LRH1 (Liver receptor homologue-1) agonist with IC50 of 320 nM. ML179 shows anti-proliferation activity in MDA-MB-231 cells. ML179 has the potential for the research of ER-negative breast cancer [1].
    ML179

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