1,2-DLPC
Based on 3 publication(s) in Google Scholar
1,2-DLPC (1,2-Dilauroyl-sn-glycero-3-phosphocholine) is a ligand for LRH-1 agonists. 1,2-DLPC is a phospholipid used in the synthesis of liposomes. 1,2-DLPC enhances fat breakdown and apoptosis in fat cells through a TNFα-dependent pathway, while also inhibiting palmitate-induced insulin resistance through PPARα-mediated inflammation in muscle cells.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 18194-25-7
- Formula: C32H64NO8P
- Molecular Weight:621.83
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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DOPE -
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Phosphatidylcholines,soya
Publications Citing Use of MedChemExpress (MCE) 1,2-DLPC
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Biological Activity
Description
IC50 & Target
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PPARα |
In Vitro
1,2-DLPC (10-50 mg/mL, 24 h) increases the insulin sensitivity of muscle fibers treated with palmitic acid and induces lipolysis in fat cells[3].
1,2-DLPC (10-50 mg/mL, 24 h) treatment increases the expression levels of peroxisome proliferator-activated receptor α (PPARα) in C2C12 muscle cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:3T3-L1
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Concentration:10, 50 mg/mL
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Incubation Time:24 h
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Result:Enhanced the release of TNF-α and increased the expression of caspase3.
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Cell Line:C2C12
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Concentration:10, 50 mg/mL
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Incubation Time:24 h
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Result:Enhanced PPARα expression and inhibited palmitate-induced phosphorylation of inflammatory markers NFκB and IκB.
Chemical Information
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CAS No. 18194-25-7
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Appearance Solid
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Molecular Weight 621.83
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Formula C32H64NO8P
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Color White to off-white
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SMILES
CCCCCCCCCCCC(OC[C@@H](OC(CCCCCCCCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O)=O
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Synonyms
1,2-Dilauroyl-sn-glycero-3-phosphocholine
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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Cell Prolif
LRH-1 activation alleviates diabetes-induced podocyte injury by promoting GLS2-mediated glutaminolysis. [Abstract]2023 Nov;56(11):e13479. PMID: 37057309 -
NPJ Vaccines
mRNA-lipid nanoparticle vaccines provide protection against lethal Nipah virus infection. [Abstract]2025 Dec 19. PMID: 41419782 -
Ren Fail
Targeting LRH-1 alleviates diabetes-induced lipotoxicity in podocytes: role of PLIN5-mediated lipid droplet turnover. [Abstract]2026 Dec;48(1):2670806. PMID: 42135621
Solvent & Solubility
In Vitro:
Ethanol : 100 mg/mL (160.82 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.02 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% EtOH 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (4.02 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (274 KB)
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SDS (644 KB)
- English - EN (644 KB)
- Français - FR (644 KB)
- Deutsch - DE (644 KB)
- Norwegian - NO (644 KB)
- Español - ES (644 KB)
- Swedish - SV (644 KB)
- Italian - IT (644 KB)
- Korean - KR (644 KB)
- Portuguese - PT (644 KB)
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Handling Instructions (2659 KB)
References
[1]. Matthew E Nipper, et al. Detection of liposome membrane viscosity perturbations with ratiometric molecular rotors. Biochimie. 2011 Jun;93(6):988-94. [Content Brief]
[2]. Jae Man Lee, et al. A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature. 2011 May 25;474(7352):506-10. [Content Brief]
[3]. Jinwoo Park, et al. 1,2-Dilinoleoyl-sn-glycero-3-phosphocholine increases insulin sensitivity in palmitate-treated myotubes and induces lipolysis in adipocytes. Biochem Biophys Res Commun. 2020 Nov 26;533(1):162-167. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| Ethanol | 1 mM | 1.6082 mL | 8.0408 mL | 16.0816 mL | 40.2039 mL |
| 5 mM | 0.3216 mL | 1.6082 mL | 3.2163 mL | 8.0408 mL | |
| 10 mM | 0.1608 mL | 0.8041 mL | 1.6082 mL | 4.0204 mL | |
| 15 mM | 0.1072 mL | 0.5361 mL | 1.0721 mL | 2.6803 mL | |
| 20 mM | 0.0804 mL | 0.4020 mL | 0.8041 mL | 2.0102 mL | |
| 25 mM | 0.0643 mL | 0.3216 mL | 0.6433 mL | 1.6082 mL | |
| 30 mM | 0.0536 mL | 0.2680 mL | 0.5361 mL | 1.3401 mL | |
| 40 mM | 0.0402 mL | 0.2010 mL | 0.4020 mL | 1.0051 mL | |
| 50 mM | 0.0322 mL | 0.1608 mL | 0.3216 mL | 0.8041 mL | |
| 60 mM | 0.0268 mL | 0.1340 mL | 0.2680 mL | 0.6701 mL | |
| 80 mM | 0.0201 mL | 0.1005 mL | 0.2010 mL | 0.5025 mL | |
| 100 mM | 0.0161 mL | 0.0804 mL | 0.1608 mL | 0.4020 mL |
1,2-DLPC Related Classifications
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