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Results for "

MHC-II

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

1

Peptides

5

Inhibitory Antibodies

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P99027
    Ieramilimab

    LAG525; IMP701

    		 LAG-3 Cancer
    Ieramilimab (LAG525; IMP701) is a humanized IgG4 monoclonal antibody that binds to LAG-3, resulting in inhibition of LAG-3 interaction with MHC-II molecules .
    Ieramilimab
  • HY-P99573
    Tebotelimab

    MGD-013

    		 LAG-3 Inflammation/Immunology Cancer
    Tebotelimab (MGD-013) is a humanized IgG4κ bispecific PD-1/LAG-3 dual-affinity re-targeting (DART) antibody. Tebotelimab binds cell-surface expressed PD-1 and LAG-3 with EC50s of 1.65 nM and 0.41 nM in NS0 cells, respectively. Tebotelimab blocks PD-1/PD-L1, PD-1/PD-L2 and LAG-3/HLA (MHC-II) interactions and PD-1 signaling. Tebotelimab restores exhausted T-cell responses and and enhances antitumour immunity .
    Tebotelimab
  • HY-112026
    1-Adamantaneethanol

    		Others Inflammation/Immunology
    1-Adamantaneethanol, a hapten, influences peptide binding by MHC II .
    1-Adamantaneethanol
  • HY-P99736
    Miptenalimab

    BI-754111

    		 LAG-3 Cancer
    Miptenalimab (BI-754111) is an anti-human LAG-3 antibody (KD: 88.6 nM for h LAG-3). Miptenalimab blocks the interaction of LAG-3 with its ligand MHC-II .
    Miptenalimab
  • HY-157280
    AdCaPy

    		Others Inflammation/Immunology
    AdCaPy is an MHC II antigen loading catalyst that accelerates the loading of peptide antigens by MHC II. AdCaPy is a useful molecular tool for enhancing immune responses .
    AdCaPy
  • HY-157277
    AdBeSA

    		Others Cancer
    AdBeSA is a hapten. AdBeSA can influence peptide binding by MHC II .
    AdBeSA
  • HY-157171
    Ac-YR-NH2

    		Others Inflammation/Immunology
    Ac-YR-NH2 is a small molecule modulator of MHC class II antigen presentation. Ac-YR-NH2 can influence peptide binding by MHC II to influence immune response .
    Ac-YR-NH2
  • HY-157269
    J10-1

    		Others Inflammation/Immunology
    J10-1 is a hapten. J10-1 promotes peptide exchange of all DR alleles (DR1, DR2, DR4 (DRB1*0401)) and promotes peptide binding to MHC II, which can be used in the study of immune regulation .
    J10-1
  • HY-P99156
    Relatlimab

    BMS-986016

    		 LAG-3 Cancer
    Relatlimab (BMS-986016) is a human monoclonal antibody anti-LAG-3 antibody generated by immunization of transgenic mice bearing human immunoglobulin miniloci with recombinant LAG-3 protein. Relatlimab blocks LAG-3/MHC II interaction with an IC50 value of 0.67 nM and LAG-3/FGL1 interaction with an IC50 value of 0.019 nM. Relatlimab can be used in research of cancer .
    Relatlimab
  • HY-157992
    LM-021

    		Interleukin Related Caspase Lactate Dehydrogenase Reactive Oxygen Species Neurological Disease Inflammation/Immunology
    LM-021 is a coumarin-chalcone derivative with anti-aggregatory, antioxidant, neuroprotective and anti-inflammatory properties which suppresses nitric oxide (NO), IL-1β, IL-6, TNF-α production, CD68 antigen (CD68) and histocompatibility-2 (MHCII) expression. LM-021 also attenuates the increase of caspase 1 activity, lactate dehydrogenase release and ROS level. LM-021 can be used for neurological research .
    LM-021

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