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Nef

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Chloride Channel (1) HIV (7) Src (2)
By Research Areas:	Infection (7)

8

Inhibitors & Agonists

2

Peptides

1

Recombinant Proteins

3

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138562

HIV-1 Nef-IN-1

HIV Infection

HIV-1 Nef-IN-1 is an HIV-1 Nef protein inhibitor that efficiently competes for Nef-SH3Hck interactions with a K_d of 6.7 μM .

Hck-IN-1	Src HIV	Infection
Hck-IN-1 (compound B9), a diphenylpyrazolo compound, is a selective Nef-dependent Hck inhibitor with IC₅₀s of 2.8 μM, >20 μM for Nef:Hck complex and Hck, respectively. Hck-IN-1 is a direct and wide HIV-1 Nef antagonists with an IC₅₀ of 100-300 nM for wild-type HIV-1 replication. Hck-IN-1 binds pocket residue Asn126 and has anti-retroviral activity .

R(+)-Methylindazone 2 Publications Verification R(+)-IAA-94	Chloride Channel	Others
R(+)-Methylindazone (R(+)-IAA-94) is a potent indanyloxyacetic acid blocker of epithelial chloride channels. R(+)-Methylindazone inhibits Nef-sdAb19 (single-domain antibody) interaction and binds to negative factor (Nef) .

HY-121718

DQBS

HIV Infection

DQBS can bind to HIV-1 nef protein, and inhibits Nef-dependent HIV replication .

ZINC04177596	HIV	Infection
ZINC04177596 is a potent HIV-negative factor *(HIV-Nef) protein* inhibitor. Nef is an accessory gene product of HIV and has an imperative role in viral replication and AIDS pathogenesis .

HY-147314

HIV-IN-6

HIV Src Infection

HIV-IN-6 is a HIV-Ⅰ viral replication inhibitor by targeting Src family kinases (SFK) that interact with Nef protein of the virus, such as Hck .

Tat-beclin 1 scrambled	HIV	Infection
Tat-beclin 1 scrambled is the scrambled part and a scrambled control of Tat-beclin 1 (HY-P2260), which is derived from a region of the autophagy protein, beclin 1. beclin 1 induces autophagy via binding human immunodeficiency virus, HIV-1 Nef and interacting with negative regulator GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens, such as HIV-1. Tat-beclin 1 also reduces mortality in mice infected with chikungunya or West Nile virus .

Tat-beclin 1 scrambled TFA	HIV	Infection
Tat-beclin 1 scrambled TFA is the scrambled part and a scrambled control of Tat-beclin 1 (HY-P2260), which is derived from a region of the autophagy protein, beclin 1. beclin 1 induces autophagy via binding human immunodeficiency virus, HIV-1 Nef and interacting with negative regulator GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens, such as HIV-1. Tat-beclin 1 also reduces mortality in mice infected with chikungunya or West Nile virus .

Cat. No.	Product Name	Target	Research Area

Tat-beclin 1 scrambled TFA	HIV	Infection
Tat-beclin 1 scrambled TFA is the scrambled part and a scrambled control of Tat-beclin 1 (HY-P2260), which is derived from a region of the autophagy protein, beclin 1. beclin 1 induces autophagy via binding human immunodeficiency virus, HIV-1 Nef and interacting with negative regulator GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens, such as HIV-1. Tat-beclin 1 also reduces mortality in mice infected with chikungunya or West Nile virus .

Tat-beclin 1 scrambled	HIV	Infection
Tat-beclin 1 scrambled is the scrambled part and a scrambled control of Tat-beclin 1 (HY-P2260), which is derived from a region of the autophagy protein, beclin 1. beclin 1 induces autophagy via binding human immunodeficiency virus, HIV-1 Nef and interacting with negative regulator GAPR-1 (GLIPR2). Tat-beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens, such as HIV-1. Tat-beclin 1 also reduces mortality in mice infected with chikungunya or West Nile virus .

Cat. No.	Compare	Product Name	Species	Source

	S100B Protein, Canine (HEK293, Fc) Protein S100; S100 calcium-binding; Nef; S100; 100beta; S100-B	Canine	HEK293
	The S100B protein is a small zinc and calcium binding protein abundant in astrocytes with unique calcium and zinc binding sites of varying affinities. Although it binds weakly to calcium, it binds tightly to zinc, and potassium ions antagonize both. S100B Protein, Canine (HEK293, Fc) is the recombinant canine-derived S100B protein, expressed by HEK293 , with N-hFc labeled tag. The total length of S100B Protein, Canine (HEK293, Fc) is 91 a.a., with molecular weight of 40-45 kDa.

Cat. No.	Product Name	Application	Reactivity

S100B Antibody Nef; Protein S100 B; Protein S100-B; S 100 calcium binding protein beta chain; S 100 protein beta chain; S-100 protein beta chain; S-100 protein subunit beta; S100; S100 calcium binding protein beta (neural); S100 calcium-binding protein B; S100 protein b	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat, Goat
S100B Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 11 kDa, targeting to S100B. It can be used for WB,IHC-P,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat, Goat.

HY-P82322

alpha Internexin Antibody (YA2067)

INA; Nef5; Alpha-internexin; Alpha-Inx; 66 kDa neurofilament protein; NF-66; Neurofilament-66; Neurofilament 5
WB Human, Mouse, Rat

Neurofilament Medium Antibody (YA2529) NefM; Nef3; NFM; Neurofilament medium polypeptide; NF-M; 160 kDa neurofilament protein; Neurofilament 3; Neurofilament triplet M protein	WB, IHC-P, ICC/IF, IP	Human

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