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PNA backbone derivative

" in MedChemExpress (MCE) Product Catalog:

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Peptides

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Click Chemistry

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-151738
    Fmoc-Aeg(N3)-OH

    		ADC Linker Others
    Fmoc-Aeg(N3)-OH is a click chemistry reagent containing an Azide. Alkylating the Nitrogen of an amide bond results in peptoid structures, which leads to conformational restrains, like N-methylation and allows backbone derivatisation. Altering cytotoxicity, bacterial cell selectivity and receptor pharmacology through formation of peptoid derivatives have been published for Cilengitide, Piscidin 1, and MC3, MC4 and MC5 receptor agonist. This building block enables design of macrocycles through intermolecular crosslinking or backbone stabilization through intermolecular ring-closure. This compound is a potential building block for the construction of (customized) peptide nucleic acids (PNAs) and for peptoid synthesis . Fmoc-Aeg(N3)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Fmoc-Aeg(N3)-OH
  • HY-P11690
    Fmoc-Aeg-OBn

    		Biochemical Assay Reagents Cancer
    Fmoc-Aeg-OBn is a benzyl-protected N-(2-aminoethyl)-glycine PNA backbone derivative. Fmoc-Aeg-OBn serves as a key intermediate for the synthesis of Fmoc-protected PNA monomers with modified nucleobases. Fmoc-Aeg-OBn can be used to prepare PNA with unique physicochemical properties, which is suitable for antisense and gene diagnostic applications. Fmoc-Aeg-OBn is applicable to cancer-related research .
    Fmoc-Aeg-OBn

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