Fmoc-Aeg(N3)-OH

Cat. No.: HY-151738 Purity: 99.62%: Data Sheet
COA
Handling Instructions
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Fmoc-Aeg(N3)-OH is a click chemistry reagent containing an Azide. Alkylating the Nitrogen of an amide bond results in peptoid structures, which leads to conformational restrains, like N-methylation and allows backbone derivatisation. Altering cytotoxicity, bacterial cell selectivity and receptor pharmacology through formation of peptoid derivatives have been published for Cilengitide, Piscidin 1, and MC3, MC4 and MC5 receptor agonist. This building block enables design of macrocycles through intermolecular crosslinking or backbone stabilization through intermolecular ring-closure. This compound is a potential building block for the construction of (customized) peptide nucleic acids (PNAs) and for peptoid synthesis. Fmoc-Aeg(N3)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

For research use only. We do not sell to patients.

Fmoc-Aeg(N3)-OH Chemical Structure

CAS No. : 1935981-35-3

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Description

Fmoc-Aeg(N3)-OH is a click chemistry reagent containing an Azide. Alkylating the Nitrogen of an amide bond results in peptoid structures, which leads to conformational restrains, like N-methylation and allows backbone derivatisation. Altering cytotoxicity, bacterial cell selectivity and receptor pharmacology through formation of peptoid derivatives have been published for Cilengitide, Piscidin 1, and MC3, MC4 and MC5 receptor agonist. This building block enables design of macrocycles through intermolecular crosslinking or backbone stabilization through intermolecular ring-closure. This compound is a potential building block for the construction of (customized) peptide nucleic acids (PNAs) and for peptoid synthesis^[1]. Fmoc-Aeg(N3)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Molecular Weight

366.37

Formula

C₁₉H₁₈N₄O₄

CAS No.

1935981-35-3

Appearance

Solid

SMILES

[N-]=[N+]=NCCN(CC(O)=O)C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (272.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7295 mL	13.6474 mL	27.2948 mL
5 mM	0.5459 mL	2.7295 mL	5.4590 mL
10 mM	0.2729 mL	1.3647 mL	2.7295 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.62%

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COA (250 KB)

Handling Instructions (2659 KB)

References

[1]. Fernández-Llamazares AI, et al. The backbone N-(4-azidobutyl) linker for the preparation of peptide chimera. Org Lett. 2013 Sep 6;15(17):4572-5. [Content Brief]

[2]. Kruijtzer JA, et al. Peptoid-peptide hybrids as potent novel melanocortin receptor ligands. J Med Chem. 2005 Jun 30;48(13):4224-30. [Content Brief]

[3]. Kim JK, et al. Structural flexibility and the positive charges are the key factors in bacterial cell selectivity and membrane penetration of peptoid-substituted analog of Piscidin 1. Biochim Biophys Acta. 2010 Oct;1798(10):1913-25. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7295 mL	13.6474 mL	27.2948 mL	68.2370 mL
	5 mM	0.5459 mL	2.7295 mL	5.4590 mL	13.6474 mL
	10 mM	0.2729 mL	1.3647 mL	2.7295 mL	6.8237 mL
	15 mM	0.1820 mL	0.9098 mL	1.8197 mL	4.5491 mL
	20 mM	0.1365 mL	0.6824 mL	1.3647 mL	3.4119 mL
	25 mM	0.1092 mL	0.5459 mL	1.0918 mL	2.7295 mL
	30 mM	0.0910 mL	0.4549 mL	0.9098 mL	2.2746 mL
	40 mM	0.0682 mL	0.3412 mL	0.6824 mL	1.7059 mL
	50 mM	0.0546 mL	0.2729 mL	0.5459 mL	1.3647 mL
	60 mM	0.0455 mL	0.2275 mL	0.4549 mL	1.1373 mL
	80 mM	0.0341 mL	0.1706 mL	0.3412 mL	0.8530 mL
	100 mM	0.0273 mL	0.1365 mL	0.2729 mL	0.6824 mL

Fmoc-Aeg(N3)-OH Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fmoc-Aeg(N3)-OH1935981-35-3ADC LinkerAntibody-drug conjugates linkerclick chemistryAzideN-methylationPNAspeptoid synthesisInhibitorinhibitorinhibit

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Fmoc-Aeg(N3)-OH

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