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Pathways Recommended:	PROTAC

Results for "

PROTAC JAK1 degrader 1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	JAK (3) Ligands for Target Protein for PROTAC (1) E3 Ligase Ligand-Linker Conjugates (1) Interleukin Related (1) PROTACs (2) STAT (2) TNF Receptor (1)
By Research Areas:	Cancer (3) Inflammation/Immunology (1)

Targets Recommended: JAK PROTAC-Linker Conjugates for PAC PROTAC Linkers Ligands for Target Protein for PROTAC

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-162608

**PROTAC JAK1 degrader 1**	PROTACs JAK STAT	Cancer
PROTAC JAK1 degrader 1 is a **JAK1 PROTAC** degrader with a DC₅₀ of 214 nM and an IC₅₀ of 5.2 nM. PROTAC JAK1 degrader 1 inhibits the downstream JAK-STAT signaling pathway by degrading *JAK1. PROTAC* JAK1 degrader 1 exhibits antiproliferative activity in cells. PROTAC JAK1 degrader 1 can be used for research on leukemia .

HY-179715

**PROTAC JAK1/2 degrader-1**	PROTACs JAK TNF Receptor Interleukin Related STAT	Inflammation/Immunology
PROTAC JAK1/2 degrader-1 (Compound A8) is a selective **JAK1/2 PROTAC** degrader, with DC₅₀ values of 1.4 μM for JAK1 and 0.92 μM for JAK2. PROTAC JAK1/2 degrader-1 significantly inhibits the release of NO, IL-6 (IC₅₀ = 12.89 μM) and TNF-α (IC₅₀ = 17.17 μM). PROTAC JAK1/2 degrader-1 significantly alleviates inflammatory responses and colonic damage by inhibiting the JAK/STAT3 signaling pathway. PROTAC JAK1/2 degrader-1 can be used for research on colitis. (Pink: JAK1/2 ligand (HY-179716); Blue: CRBN ligand (HY-10984); Black: linker; CRBN ligand + linker (HY-131888A)) .

HY-162610

Thalidomide-alkyne-C4-NHBoc	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-alkyne-C4-NHBoc is an E3 Ligase Ligand-Linker Conjugate. Thalidomide-alkyne-C4-NHBoc can be used to synthesize PROTAC JAK1 degrader 1 (HY-162608) .

HY-174430

WWQ-131	Ligands for Target Protein for PROTAC JAK	Cancer
WWQ-131 is a potent selective JAK2 inhibitor with an IC₅₀ of 2.56 nM. WWQ-131 shows >252-fold selectivity over *JAK1, JAK3, and TYK2. WWQ-131 exhibits antiproliferative activity against cancer cells. WWQ-131 is the ligand for target protein* for PROTAC JAK2 degrader-1 (HY-174428). WWQ-131 can be used for the research of myeloproliferative neoplasms (MPNs) .

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MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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PROTAC JAK1 degrader 1

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