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Results for "

Piezo1

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

2

Peptides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-131018
    Jedi2
    1 Publications Verification

    		 Piezo Channel Neurological Disease Inflammation/Immunology
    Jedi2 is a Piezo1 activator, but not a specific Piezo2 activator. Jedi2 binds to the mouse Piezo1 proteins with a Kd of 2770  μM [1].
    Jedi2
  • HY-18723
    Yoda 1
    20+ Cited Publications

    		 Piezo Channel Akt ERK Potassium Channel Cardiovascular Disease
    Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). Yoda 1 enhances Ca 2+ influx followed by activation of the calcium-activated potassium channel KCa3.1 and inhibition of Rac1 activation [1] .
    Yoda <em>1</em>
  • HY-126010
    Dooku1
    5 Publications Verification

    		 Piezo Channel Others
    Dooku1 is a reversibly Yoda1 antagonist with IC50 value of 1.3 μM and 1.5 μM for 2 μM Yoda1-induced Ca 2+ entry HEK 293 cells and HUVECs, respectively. Dooku1 can disrupt Yoda1-induced Piezo1 channel activity and inhibit Yoda1-induced relaxation of aorta. Dooku1 can be used for vascular physiology and disease research [1].
    Dooku<em>1</em>
  • HY-P1410A
    GsMTx4 TFA
    Maximum Cited Publications
    28 Publications Verification

    		 TRP Channel Piezo Channel Cardiovascular Disease Neurological Disease Inflammation/Immunology
    GsMTx4 TFA is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 TFA also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 TFA is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology [1] .
    GsMTx4 TFA
  • HY-RS10483
    PIEZO1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA)
    PIEZO1 Human Pre-designed siRNA Set A contains three designed siRNAs for PIEZO1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    PIEZO1 Human Pre-designed siRNA Set A
    PIEZO1 Human Pre-designed siRNA Set A
  • HY-P1410
    GsMTx4
    Maximum Cited Publications
    28 Publications Verification

    		 TRP Channel Piezo Channel Cardiovascular Disease Neurological Disease Inflammation/Immunology
    GsMTx4 is a spider venom peptide that selectively inhibits cationic-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 also blocks cation-selective stretch-activated channels (SACs) , attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglial reactivity. GsMTx4 is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology [1] .
    GsMTx4

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