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Results for "

SMAD4

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

1

Screening Libraries

1

Peptides

1

Recombinant Proteins

6

Antibodies

3

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-RS13395
    SMAD4 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SMAD4 Human Pre-designed siRNA Set A contains three designed siRNAs for SMAD4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SMAD4 Human Pre-designed siRNA Set A
    SMAD4 Human Pre-designed siRNA Set A
  • HY-149414
    MY-673

    		Microtubule/Tubulin Apoptosis ERK TGF-beta/Smad Cancer
    MY-673 is a colchicine binding site inhibitor (CBSI), that inhibits tubulin polymerization. MY-673 inhibits the ERK signaling pathway, which in turn affects SMAD4 protein expression levels in the TGF-β/SMAD pathway. MY-673 inhibited cell proliferation, migration and induced apoptosis in vivo and in vitro .
    MY-673
  • HY-RS17346
    Smad4 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Smad4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Smad4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Smad4 Mouse Pre-designed siRNA Set A
    Smad4 Mouse Pre-designed siRNA Set A
  • HY-RS23800
    Smad4 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Smad4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Smad4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Smad4 Rat Pre-designed siRNA Set A
    Smad4 Rat Pre-designed siRNA Set A
  • HY-179228
    AN02

    		CTLA-4 TGF-beta/Smad Cancer
    AN02 is a derivative of Curcumin (HY-N0005). AN02 inhibits the proliferation and clonogenicity, migration and invasion of ovarian cancer cells. AN02 dose-dependently upregulates the expression of APC and mediates the degradation of CTLA-4 through SMAD4. In the small xenograft model, AN02 significantly inhibits tumor growth and reverses the tumor immune-suppressive microenvironment. AN02, when combined with Ipilimumab (HY-P9901), can enhance efficacy and inhibit epithelial-mesenchymal transition. AN02 can be used for the study of ovarian cancer .
    AN02
  • HY-P11223
    CMF9

    		TGF-beta/Smad Inflammation/Immunology
    CMF9, a cyclic peptide molecule, is an inhibitor of the SMAD2-SMAD4 interaction. CMF9 effectively blocks the formation of the heterodimeric complex of SMAD2 and SMAD4 by inhibiting the phosphorylation of SMAD2. CMF9 has no effect on the phosphorylation of SMAD3 or SMAD1/5/8. CMF9 downregulates the expression of fibrotic markers α-SMA and COL1A1. CMF9 exhibits potent anti-fibrotic effects in mouse models by promoting the degradation of pathological extracellular matrix (ECM) and inhibiting inflammation. CMF9 can be used for the study of liver fibrosis .
    CMF9

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