Sofosbuvir

By Targets:	Drug Metabolite (4) HCV (16) Isotope-Labeled Compounds (1)
By Research Areas:	Cancer (1) Infection (15)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15005

Sofosbuvir

Maximum Cited Publications

101 Publications Verification

GS-7977; PSI-7977
HCV Infection

Sofosbuvir (GS-7977) is an HCV RNA replication inhibitor with an EC₅₀ of 92 nM .

*Sofosbuvir* Maximum Cited Publications 101 Publications Verification GS-7977; PSI-7977	HCV	Infection
Sofosbuvir (GS-7977) is an HCV RNA replication inhibitor with an EC₅₀ of 92 nM .

HY-15005C

Sofosbuvir impurity A	HCV	Infection
Sofosbuvir impurity A, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.

HY-I1196

Sofosbuvir impurity L	HCV	Infection
Sofosbuvir impurity L, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.

HY-I0735

Sofosbuvir impurity M	HCV	Infection
Sofosbuvir impurity M, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.

HY-I0512

Sofosbuvir impurity I	HCV	Infection
Sofosbuvir impurity I, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.

HY-I0513

Sofosbuvir impurity N	HCV	Others
Sofosbuvir impurity N, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.

HY-I0406

Sofosbuvir impurity F	HCV	Infection
Sofosbuvir impurity F, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.

HY-I0408

Sofosbuvir impurity G	HCV	Others
Sofosbuvir impurity G, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.

HY-I0515

Sofosbuvir impurity K	HCV	Infection
Sofosbuvir impurity K, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.

HY-I0938

Sofosbuvir impurity H	HCV	Infection
Sofosbuvir impurity H, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.

HY-I0975

Sofosbuvir impurity J	HCV	Infection
Sofosbuvir impurity J, an diastereoisomer of Sofosbuvir, is the impurity of Sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.

HY-15005B

Sofosbuvir impurity C	Drug Metabolite	Others
Sofosbuvir impurity C is an impurity of Sofosbuvir, Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.

HY-I0719

Sofosbuvir impurity B	Drug Metabolite	Others
Sofosbuvir impurity B is an impurity of Sofosbuvir, Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.

HY-I0723

Sofosbuvir impurity D	Drug Metabolite	Others
Sofosbuvir impurity D is an impurity of Sofosbuvir, Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.

HY-I0727

Sofosbuvir impurity E	Drug Metabolite	Others
Sofosbuvir impurity E is an impurity of Sofosbuvir, Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.

HY-15005S1

Sofosbuvir-d6 PSI-7977-d₆; GS-7977-d₆	HCV	Infection
Sofosbuvir-d₆ is the deuterium labeled Sofosbuvir. Sofosbuvir (PSI-7977) is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.

HY-15005S

Sofosbuvir-13C,d3 PSI-7977-¹³C,d₃; GS-7977-¹³C,d₃	Isotope-Labeled Compounds HCV	Infection
Sofosbuvir- ¹³C,d₃ is the deuterium labeled Sofosbuvir. Sofosbuvir (PSI-7977) is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.

HY-15236S

PSI-6206-13C,d3 RO-2433-¹³C,d₃; GS-331007-¹³C,d₃; Sofosbuvir metabolite GS-331007-¹³C,d₃	HCV	Infection
PSI-6206- ¹³C,d₃ is the deuterium labeled PSI-6206. PSI-6206 is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC90 of >100 μM.

HY-I0726

Enantiomer of Sofosbuvir	Others	Infection
Enantiomer of Sofosbuvir is an enantiomer of Sofosbuvir, a prescription medicine for the treatment of patients with chronic hepatitis C. There is no biological activity report on enantiomer of Sofosbuvir until now.

HY-15745

PSI-7409	HCV	Cancer
PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977). Sofosbuvir (PSI-7977) is a selective and highly active nucleotide analog inhibitor of HCV.

HY-15745A

PSI-7409 tetrasodium 5+ Cited Publications	HCV	Infection
PSI-7409 tetrasodium is an active 5'-triphosphate metabolite of sofosbuvir (PSI-7977), inhibiting HCV NS5B polymerases, with IC₅₀s of 1.6, 2.8, 0.7 and 2.6 μM for GT 1b_Con1, GT 2a_JFH1, GT 3a, and GT 4a NS5B polymerases, respectively.

Cat. No.	Product Name	Target	Research Area

HY-59121A

Isopropyl ((R)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate	Peptides	Infection
Isopropyl ((R)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate can be used to synthesis Sofosbuvir (HY-15005) to avoid the production of sofibuvir degradation impurities .

Cat. No.	Product Name	Chemical Structure

HY-15005S1

Sofosbuvir-d6
Sofosbuvir-d₆ is the deuterium labeled Sofosbuvir. Sofosbuvir (PSI-7977) is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.

HY-15236S

PSI-6206-13C,d3
PSI-6206- ¹³C,d₃ is the deuterium labeled PSI-6206. PSI-6206 is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC90 of >100 μM.

HY-15005S

Sofosbuvir-13C,d3
Sofosbuvir- ¹³C,d₃ is the deuterium labeled Sofosbuvir. Sofosbuvir (PSI-7977) is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
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Inhibitors & Agonists

Peptides

Isotope-Labeled Compounds