Sofosbuvir-d6
Based on 1 publication(s) in Google Scholar
Sofosbuvir-d6 is the deuterium labeled Sofosbuvir. Sofosbuvir (PSI-7977) is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.
For research use only. We do not sell to patients.
- Purity: 98.07%
- CAS No.: 1868135-06-1
- Formula: C22H23D6FN3O9P
- Molecular Weight:535.49
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Sofosbuvir-d6
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1868135-06-1
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Unlabeled Cas 1190307-88-0
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Appearance Solid
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Molecular Weight 535.49
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Formula C22H23D6FN3O9P
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Color White to off-white
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SMILES
O=C1N([C@H]2[C@]([C@H](O)[C@@H](CO[P@](OC3=CC=CC=C3)(N[C@@H](C)C(OC(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)=O)O2)(C)F)C=CC(N1)=O
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Synonyms
PSI-7977-d6; GS-7977-d6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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ACS Appl Mater Interfaces
Reducing Small Molecule Adsorption in a PDMS-Based Microphysiological System of the Female Reproductive Tract via Parylene-C Coating to Improve Mechanistic Studies. [Abstract]2026 Jan 21;18(2):3565-3577. PMID: 41493331
Solvent & Solubility
DMSO : 50 mg/mL (93.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 25 mg/mL (46.69 mM; ultrasonic and warming and heat to 50°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (255 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.8674 mL | 9.3372 mL | 18.6745 mL | 46.6862 mL |
| 5 mM | 0.3735 mL | 1.8674 mL | 3.7349 mL | 9.3372 mL | |
| 10 mM | 0.1867 mL | 0.9337 mL | 1.8674 mL | 4.6686 mL | |
| 15 mM | 0.1245 mL | 0.6225 mL | 1.2450 mL | 3.1124 mL | |
| 20 mM | 0.0934 mL | 0.4669 mL | 0.9337 mL | 2.3343 mL | |
| 25 mM | 0.0747 mL | 0.3735 mL | 0.7470 mL | 1.8674 mL | |
| 30 mM | 0.0622 mL | 0.3112 mL | 0.6225 mL | 1.5562 mL | |
| 40 mM | 0.0467 mL | 0.2334 mL | 0.4669 mL | 1.1672 mL | |
| DMSO | 50 mM | 0.0373 mL | 0.1867 mL | 0.3735 mL | 0.9337 mL |
| 60 mM | 0.0311 mL | 0.1556 mL | 0.3112 mL | 0.7781 mL | |
| 80 mM | 0.0233 mL | 0.1167 mL | 0.2334 mL | 0.5836 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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