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Thalidomide (Standard)

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-14658R
    Thalidomide (Standard)

    		Ligands for E3 Ligase Autophagy Apoptosis Reference Standards Inflammation/Immunology Cancer
    Thalidomide (Standard) is the analytical standard of Thalidomide. This product is intended for research and analytical applications. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ∼250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide can work as molecular glue to potentiate substrate.
    Thalidomide (Standard)
  • HY-A0003R
    Lenalidomide (Standard)

    CC-5013 (Standard)

    		 Reference Standards Ligands for E3 Ligase Molecular Glues Apoptosis Inflammation/Immunology Cancer
    Lenalidomide (Standard) is the analytical standard of Lenalidomide. This product is intended for research and analytical applications. Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells .
    Lenalidomide (Standard)
  • HY-101291R
    Iberdomide (Standard)

    CC-220 (Standard)

    		 Reference Standards Ligands for E3 Ligase Apoptosis Molecular Glues Inflammation/Immunology Cancer
    Iberdomide (Standard) is the analytical standard of Iberdomide. This product is intended for research and analytical applications. Iberdomide (CC-220) is an orally active and potent cereblon (CRBN) E3 ligase modulator (CELMoD) with an IC50 of ~150 nM for cereblon-binding affinity. Iberdomide, a derivative of Thalidomide (HY-14658), has antitumor and immunostimulatory activities .
    Iberdomide (Standard)
  • HY-A0003BR
    Lenalidomide hemihydrate (Standard)

    CC-5013 hemihydrate (Standard)

    		 Ligands for E3 Ligase Molecular Glues Apoptosis Reference Standards Cancer
    Lenalidomide (hemihydrate) (Standard) is the analytical standard of Lenalidomide (hemihydrate). This product is intended for research and analytical applications. Lenalidomide hemihydrate (CC-5013 hemihydrate), a derivative of Thalidomide, acts as molecular glue. Lenalidomide hemihydrate is an orally active immunomodulator. Lenalidomide hemihydrate (CC-5013 hemihydrate) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide hemihydrate (CC-5013 hemihydrate) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells .
    Lenalidomide hemihydrate (Standard)
  • HY-23095R
    Thalidomide-5-OH (Standard)

    		Ligands for E3 Ligase Autophagy Apoptosis Cancer
    Thalidomide-5-OH (Standard) is the analytical standard of Thalidomide-5-OH. This product is intended for research and analytical applications. Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs .
    Thalidomide-5-OH (Standard)
  • HY-101460R
    Tz-Thalidomide (Standard)

    		PROTACs Reference Standards Molecular Glues Epigenetic Reader Domain Cancer
    Tz-Thalidomide (Standard) is the analytical standard of Tz-Thalidomide (HY-101460). This product is intended for research and analytical applications. Tz-Thalidomide is a tetrazine tagged Thalidomide (HY-14658) (Ligands for E3 Ligase). Tz-Thalidomide has binding affinity for BRD4, with IC50s of 46.25 μM (BRD4-1) and 62.55 μM (BRD4-2). Tz-Thalidomide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups .
    Tz-Thalidomide (Standard)
  • HY-103596R
    Thalidomide-4-OH (Standard)

    Cereblon ligand 2 (Standard); E3 ligase Ligand 2 (Standard)

    		 Ligands for E3 Ligase Autophagy Apoptosis Reference Standards Cancer
    Thalidomide-4-OH (Standard) is the analytical standard of Thalidomide-4-OH (HY-103596). This product is intended for research and analytical applications. Thalidomide-4-OH (Cereblon ligand 2) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-4-OH (Cereblon ligand 2) can be connected to the ligand for protein by a linker to form PROTACs .
    Thalidomide-4-OH (Standard)
  • HY-103597R
    Thalidomide-O-COOH (Standard)

    Cereblon ligand 3 (Standard); E3 ligase Ligand 3 (Standard)

    		 Ligands for E3 Ligase Reference Standards Cancer
    Thalidomide-O-COOH (Standard) is the analytical standard of Thalidomide-O-COOH (HY-103597). This product is intended for research and analytical applications. Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs .
    Thalidomide-O-COOH (Standard)
  • HY-107440AR
    Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride (Standard)

    		Reference Standards E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis Cancer
    Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride (Standard) is the analytical standard of Thalidomide-O-amido-PEG3-C2-NH2 (hydrochloride) (HY-107440A). This product is intended for research and analytical applications. Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology .
    Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride (Standard)
  • HY-103612R
    Thalidomide-O-amido-C3-COOH (Standard)

    Cereblon Ligand-Linker Conjugates 7 (Standard); E3 ligase Ligand-Linker Conjugates 15 (Standard)

    		 Reference Standards E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis Cancer
    Thalidomide-O-amido-C3-COOH (Standard) is the analytical standard of Thalidomide-O-amido-C3-COOH (HY-103612). This product is intended for research and analytical applications. Thalidomide-O-amido-C3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
    Thalidomide-O-amido-C3-COOH (Standard)
  • HY-103615R
    Thalidomide-O-amido-C4-N3 (Standard)

    Cereblon Ligand-Linker Conjugates 4 (Standard); E3 ligase Ligand-Linker Conjugates 18 (Standard)

    		 Reference Standards E3 Ligase Ligand-Linker Conjugates Others
    Thalidomide-O-amido-C4-N3 (Standard) is the analytical standard of Thalidomide-O-amido-C4-N3 (HY-103615). This product is intended for research and analytical applications. Thalidomide-O-amido-C4-N3 is a synthetic E3 ligase ligand-linker conjugate, consisting of a cereblon ligand based on Thalidomide (HY-14658) and a linker.
    Thalidomide-O-amido-C4-N3 (Standard)
  • HY-103614R
    Thalidomide-O-amido-C8-NH2 TFA (Standard)

    Cereblon Ligand -Linker Conjugates 2 TFA (Standard); E3 Ligase Ligand-Linker Conjugates 20 TFA (Standard)

    		 Reference Standards E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis Cancer
    Thalidomide-O-amido-C8-NH2 TFA (Standard) is the analytical standard of Thalidomide-O-amido-C8-NH2 TFA (HY-103614). This product is intended for research and analytical applications. Thalidomide-O-amido-C8-NH2 TFA (Cereblon Ligand -Linker Conjugates 2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
    Thalidomide-O-amido-C8-NH2 TFA (Standard)
  • HY-103613R
    Thalidomide-O-amido-C4-NH2 TFA (Standard)

    Cereblon Ligand-Linker Conjugates 6 TFA (Standard); E3 ligase Ligand-Linker Conjugates 19 TFA (Standard)

    		 Reference Standards E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis Others
    Thalidomide-O-amido-C4-NH2 TFA (Standard) is the analytical standard of Thalidomide-O-amido-C4-NH2 TFA (HY-103613). This product is intended for research and analytical applications. Thalidomide-O-amido-C4-NH2 TFA (Cereblon Ligand-Linker Conjugates 6 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
    Thalidomide-O-amido-C4-NH2 TFA (Standard)
  • HY-103611R
    Thalidomide-O-amido-PEG3-C2-NH2 TFA (Standard)

    Cereblon Ligand-Linker Conjugates 3 TFA (Standard); E3 ligase Ligand-Linker Conjugates 14 TFA (Standard)

    		 Reference Standards E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis Cancer
    Thalidomide-O-amido-PEG3-C2-NH2 TFA (Standard) is the analytical standard of Thalidomide-O-amido-PEG3-C2-NH2 TFA (HY-103611). This product is intended for research and analytical applications. Thalidomide-O-amido-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.
    Thalidomide-O-amido-PEG3-C2-NH2 TFA (Standard)
  • HY-138793R
    2-(2,6-Dioxopiperidin-3-yl)phthalimidine (Standard)

    EM-12 (Standard)

    		 TNF Receptor Reference Standards Cancer
    2-(2,6-Dioxopiperidin-3-yl)phthalimidine (Standard) is the analytical standard of 2-(2,6-Dioxopiperidin-3-yl)phthalimidine. This product is intended for research and analytical applications. 2-(2,6-Dioxopiperidin-3-yl)phthalimidine (EM-12), a teratogenic Thalidomide analogue, is more active than Thalidomide and is much more stable for hydrolysis. 2-(2,6-Dioxopiperidin-3-yl)phthalimidine enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomas .
    2-(2,6-Dioxopiperidin-3-yl)phthalimidine (Standard)

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