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Yap1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Arp2/3 Complex (1) Small Interfering RNA (siRNA) (3) YAP (4)
By Research Areas:	Cancer (2) Infection (1)

7

Inhibitors & Agonists

1

Natural
Products

1

Recombinant Proteins

3

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

K-975 5+ Cited Publications	YAP	Cancer
K-975 is a potent, selective and orally active TEAD inhibitor, with a strong inhibitory effect against protein-protein interactions between *YAP1/TAZ* and TEAD. K-975 covalently binds to Cys359 located in the palmitate-binding pocket of TEAD via an acrylamide structure. K-975 exhibits antitumor activity on malignant pleural mesothelioma ^[1].

YAP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
YAP1 Human Pre-designed siRNA Set A contains three designed siRNAs for YAP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

YAP1 Human Pre-designed siRNA Set A YAP1 Human Pre-designed siRNA Set A

Yap1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Yap1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Yap1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Yap1 Mouse Pre-designed siRNA Set A Yap1 Mouse Pre-designed siRNA Set A

Yap1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Yap1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Yap1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Yap1 Rat Pre-designed siRNA Set A Yap1 Rat Pre-designed siRNA Set A

HY-156024

TEAD-IN-6

YAP Others

TEAD-IN-6 (Example 11-1) is a TEAD modulator that blocks the interaction between YAP1/TAZ and TEAD. TEAD-IN-6 can be used in cancer research ^[1].

TED-347 4 Publications Verification	YAP	Cancer
TED-347 is a potent, irreversible, covalent and allosteric inhibitor at YAP-TEAD protein-protein interaction with an EC₅₀ of 5.9 μM for TEAD4⋅Yap1 protein-protein interaction. TED-347 specifically and covalently bonds with Cys-367 within the central pocket of TEAD4 with a K_i of 10.3 μM. TED-347 blocks TEAD transcriptional activity and has antitumor activity ^[1].

Cytochalasin D Maximum Cited Publications 40 Publications Verification Zygosporin A; NSC 209835	Arp2/3 Complex Antibiotic YAP	Infection
Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap .

Cat. No.	Compare	Product Name	Species	Source

	YAP1 Protein, Human (P.pastoris, His) Transcriptional coactivator Yap1; Yes-associated protein 1; Yap65	Human	P. pastoris
	YAP1 is a multifunctional transcriptional regulator and an important downstream target in the Hippo signaling pathway, affecting organ size control and tumor suppression through proliferation and apoptosis regulation. STK3/MST2 and STK4/MST1 phosphorylate together with SAV1, inactivating YAP1 and WWTR1/TAZ oncoproteins. YAP1 Protein, Human (P.pastoris, His) is the recombinant human-derived YAP1 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of YAP1 Protein, Human (P.pastoris, His) is 504 a.a., with molecular weight of ~68 kDa.

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