1. Cytoskeleton
    Anti-infection
    Stem Cell/Wnt
  2. Arp2/3 Complex
    Bacterial
    Antibiotic
    YAP
  3. Cytochalasin D

Cytochalasin D (Synonyms: Zygosporin A; NSC 209835)

Cat. No.: HY-N6682 Purity: >99.0%
Handling Instructions

Cytochalasin D (Zygosporin A; NSC 209835) is a potent and cell-permeable inhibitor of actin polymerization derived from fungus, inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D (Zygosporin A; NSC 209835) also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells.Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of YAP.

For research use only. We do not sell to patients.

Cytochalasin D Chemical Structure

Cytochalasin D Chemical Structure

CAS No. : 22144-77-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 1396 In-stock
Estimated Time of Arrival: December 31
1 mg USD 250 In-stock
Estimated Time of Arrival: December 31
5 mg   Get quote  
10 mg   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

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Description

Cytochalasin D (Zygosporin A; NSC 209835) is a potent and cell-permeable inhibitor of actin polymerization derived from fungus, inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D (Zygosporin A; NSC 209835) also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells[1][2][3].Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment[4]. Cytochalasin D induces phosphorylation and cytoplasmic retention of YAP[5].

IC50 & Target

G-actin[1]

Clinical Trial
Molecular Weight

507.62

Formula

C₃₀H₃₇NO₆

CAS No.

22144-77-0

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (197.00 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9700 mL 9.8499 mL 19.6998 mL
5 mM 0.3940 mL 1.9700 mL 3.9400 mL
10 mM 0.1970 mL 0.9850 mL 1.9700 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: >99.0%

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Keywords:

Cytochalasin DZygosporin A NSC 209835NSC209835NSC 209835NSC-209835Arp2/3 ComplexBacterialAntibioticYAPActin-related protein 2/3 complex Yes-associated proteinInhibitorinhibitorinhibit

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Cytochalasin D
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HY-N6682
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