1. Cytoskeleton
    Anti-infection
  2. Arp2/3 Complex
    Fungal
  3. Jasplakinolide

Jasplakinolide 

Cat. No.: HY-P0027
Handling Instructions

Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a Kd of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity.

For research use only. We do not sell to patients.

Jasplakinolide Chemical Structure

Jasplakinolide Chemical Structure

CAS No. : 102396-24-7

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Description

Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a Kd of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity[1][2].

In Vitro

Jasplakinolide has an IC50 of 35 nM for the antiproliferative effect of jasplakinolide on PC3 prostate carcinoma cells[2].
Jasplakinolide (10 μM; for 2 hours) generates binucleated cells when applied during mitosis. Jasplakinolide induces the formation of F-actin-containing apical extensions in Toxoplasma gondii tachyzoites[2].
Jasplakinolide (1 mM; for 60 min) induces the formation of actin-containing apical extensions in isolated Toxoplasma gondii tachyzoites fixed[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

709.67

Formula

C₃₆H₄₅BrN₄O₆

CAS No.

102396-24-7

SMILES

BrC1=C(C2=CC=CC=C2N1)C[[email protected]@H](N(C([[email protected]@H](NC([[email protected]](C/C(C)=C/[[email protected]@H]3C)C)=O)C)=O)C)C(N[[email protected]](C(C=C4)=CC=C4O)([H])CC(O[[email protected]](C3)C)=O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

JasplakinolideArp2/3 ComplexFungalActin-related protein 2/3 complexactinpolymerizationinducerstabilizesF-actinphalloidincyclicpeptidemarinespongefungicidalanti-cancerInhibitorinhibitorinhibit

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Jasplakinolide
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HY-P0027
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