2. Cytoskeleton Anti-infection
  3. Arp2/3 Complex Fungal
  4. Jasplakinolide

Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a Kd of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity.

For research use only. We do not sell to patients.

CAS No. : 102396-24-7

Size Price Stock Quantity
50 μg In-stock
100 μg In-stock

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 9 publication(s) in Google Scholar

Jasplakinolide Related Antibodies

Top Publications Citing Use of Products

    Jasplakinolide purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 17:e00358.  [Abstract]

    E16.5 fetal mouse ovaries were treated with or without 5 µM Jasplakinolide for 4 days. Jasplakinolide treatment altered the size of the ovaries and the morphology of oocytes.

    Jasplakinolide purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 17:e00358.  [Abstract]

    E16.5 fetal mouse ovaries were treated with or without 5 µM Jasplakinolide for 4 days. F-actin showed abnormal aggregation in both multinucleated cysts and oocytes.

    Jasplakinolide purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep 17:e00358.  [Abstract]

    E16.5 fetal mouse ovaries were treated with or without 5 µM Jasplakinolide for 4 days. The proportion of double-nucleated oocytes increased significantly.

    Jasplakinolide purchased from MedChemExpress. Usage Cited in: Chin Med J (Engl). 2024 Jan 20;137(2):209-221.  [Abstract]

    Immunofluorescent staining of F-actin and TRIM59 in T24 cells cultured in flask, 3D matrix gels or 3D matrix gels containing Jas (20 mmol/L).

    Jasplakinolide purchased from MedChemExpress. Usage Cited in: Cell Mol Gastroenterol Hepatol. 2021;11(3):683-696.  [Abstract]

    Low doses of Jasplakinolide (actin polymerization inducer) attenuated Fg-induced VP, while both high doses of Jasplakinolide and Cytochalasin D (an inhibitor of actin polymerization) dramatically increased Fg-induced VP.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a Kd of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity[1][2].

    Cellular Effect
    Cell Line Type Value Description References
    786-0 GI50
    0.02 μM
    Compound: 1
    Growth inhibition of human 786-0 cells by sulforhodamine B assay
    Growth inhibition of human 786-0 cells by sulforhodamine B assay
    		[PMID: 20121114]
    A498 GI50
    0.03 μM
    Compound: 1
    Anticancer activity against human A498 cells
    Anticancer activity against human A498 cells
    		[PMID: 21241058]
    CA46 IC50
    0.03 μM
    Compound: 5
    Antiproliferative activity against human CA46 cells after 24 hrs
    Antiproliferative activity against human CA46 cells after 24 hrs
    		[PMID: 12088429]
    CA46 IC50
    10 nM
    Compound: 1
    Growth inhibition of human CA46 cells assessed as induction of actin assembly after 24 hrs
    Growth inhibition of human CA46 cells assessed as induction of actin assembly after 24 hrs
    		[PMID: 20678932]
    DU-145 GI50
    0.03 μM
    Compound: 1
    Anticancer activity against human DU145 cells
    Anticancer activity against human DU145 cells
    		[PMID: 21241058]
    HCT-116 GI50
    0.04 μM
    Compound: 1
    Anticancer activity against human HCT116 cells
    Anticancer activity against human HCT116 cells
    		[PMID: 21241058]
    HCT-116 GI50
    0.1 μM
    Compound: 1
    Growth inhibition of human HCT116 cells by sulforhodamine B assay
    Growth inhibition of human HCT116 cells by sulforhodamine B assay
    		[PMID: 20121114]
    HCT-15 GI50
    0.69 μM
    Compound: 1
    Growth inhibition of human HCT15 cells by sulforhodamine B assay
    Growth inhibition of human HCT15 cells by sulforhodamine B assay
    		[PMID: 20121114]
    HOP-62 GI50
    0.15 μM
    Compound: 1
    Growth inhibition of human HOP62 cells by sulforhodamine B assay
    Growth inhibition of human HOP62 cells by sulforhodamine B assay
    		[PMID: 20121114]
    IGROV-1 GI50
    0.02 μM
    Compound: 1
    Anticancer activity against human IGROV1 cells
    Anticancer activity against human IGROV1 cells
    		[PMID: 21241058]
    KB IC50
    0.013 μM
    Compound: 1, jasplakinolide
    Growth inhibition of human KB cells after 72 hrs by CellTiter 96 assay
    Growth inhibition of human KB cells after 72 hrs by CellTiter 96 assay
    		[PMID: 22364566]
    LNCaP GI50
    41 μM
    Compound: 1
    Growth inhibition against human LNCAP cells assessed as disruption of actin cytoskeleton
    Growth inhibition against human LNCAP cells assessed as disruption of actin cytoskeleton
    		[PMID: 21241058]
    LOX IMVI GI50
    0.01 μM
    Compound: 1
    Anticancer activity against human LOXIMVI cells
    Anticancer activity against human LOXIMVI cells
    		[PMID: 21241058]
    M14 GI50
    0.056 μM
    Compound: 1
    Growth inhibition of human M14 cells by sulforhodamine B assay
    Growth inhibition of human M14 cells by sulforhodamine B assay
    		[PMID: 20121114]
    MDA-MB-231 GI50
    0.01 μM
    Compound: 1
    Anticancer activity against human MDA-MB-231 cells
    Anticancer activity against human MDA-MB-231 cells
    		[PMID: 21241058]
    NCI-H522 GI50
    0.03 μM
    Compound: 1
    Anticancer activity against human NCI-H522 cells
    Anticancer activity against human NCI-H522 cells
    		[PMID: 21241058]
    OVCAR-3 GI50
    0.04 μM
    Compound: 1
    Growth inhibition of human OVCAR-3 cells by sulforhodamine B assay
    Growth inhibition of human OVCAR-3 cells by sulforhodamine B assay
    		[PMID: 20121114]
    PC-3 GI50
    65 μM
    Compound: 1
    Growth inhibition against human PC3 cells assessed as disruption of actin cytoskeleton
    Growth inhibition against human PC3 cells assessed as disruption of actin cytoskeleton
    		[PMID: 21241058]
    SF-539 GI50
    0.3 μM
    Compound: 1
    Growth inhibition of human SF539 cells by sulforhodamine B assay
    Growth inhibition of human SF539 cells by sulforhodamine B assay
    		[PMID: 20121114]
    U-251 GI50
    0.07 μM
    Compound: 1
    Anticancer activity against human U251 cells
    Anticancer activity against human U251 cells
    		[PMID: 21241058]
    In Vitro

    Jasplakinolide has an IC50 of 35 nM for the antiproliferative effect of jasplakinolide on PC3 prostate carcinoma cells[2].
    Jasplakinolide (10 μM; for 2 hours) generates binucleated cells when applied during mitosis. Jasplakinolide induces the formation of F-actin-containing apical extensions in Toxoplasma gondii tachyzoites[2].
    Jasplakinolide (1 mM; for 60 min) induces the formation of actin-containing apical extensions in isolated Toxoplasma gondii tachyzoites fixed[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Jasplakinolide Related Antibodies
    Molecular Weight

    709.67

    Formula

    C36H45BrN4O6
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    BrC1=C(C2=CC=CC=C2N1)C[C@@H](N(C([C@@H](NC([C@H](C/C(C)=C/[C@@H]3C)C)=O)C)=O)C)C(N[C@](C(C=C4)=CC=C4O)([H])CC(O[C@H](C3)C)=O)=O
    Structure Classification
    Initial Source

    marine sponge
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Sealed storage, away from moisture

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 2 mg/mL (2.82 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.4091 mL 7.0455 mL 14.0911 mL
    5 mM --- --- ---
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.56%

    SDS (394 KB)

    COA (267 KB) LCMS (180 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.4091 mL 7.0455 mL 14.0911 mL 35.2276 mL
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Jasplakinolide Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Jasplakinolide102396-24-7Arp2/3 ComplexFungalActin-related protein 2/3 complexactinpolymerizationinducerstabilizesF-actinphalloidincyclicpeptidemarinespongefungicidalanti-cancerInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Requested Quantity *

    Applicant Name *

    		 

    Salutation

    Email Address *

    		 

    Phone Number *

    Department

    		 

    Organization Name *

    City

    State

    Country or Region *

    		      

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Jasplakinolide
    Cat. No.:
    HY-P0027
    Quantity:
    MCE Japan Authorized Agent:

    Customer Review

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Lot #

    Applicant Name *

    		 

    Email Address *

    Phone Number

    		 

    Department *

    Organization Name *

    		 

    Country or Region *

    Remarks

    SAFETY DATA SHEET (SDS)

    English - EN (394 KB) Français - FR (394 KB) Deutsch - DE (394 KB) Norwegian - NO (394 KB) Español - ES (394 KB) Swedish - SV (394 KB) Italian - IT (394 KB) Korean - KR (394 KB) Portuguese - PT (394 KB)

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.