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SMIFH2 

Cat. No.: HY-16931
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SMIFH2 is a formin specific inhibitor. SMIFH2 inhibits actin polymerization by Formins and affects the actin cytoskeleton.

For research use only. We do not sell to patients.

SMIFH2 Chemical Structure

SMIFH2 Chemical Structure

CAS No. : 340316-62-3

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Description

SMIFH2 is a formin specific inhibitor. SMIFH2 inhibits actin polymerization by Formins and affects the actin cytoskeleton[1].

IC50 & Target

Formin[1]

In Vitro

SMIFH2 (25 uM; 1-16 hours) induces dynamic cytoskeletal remodelling in U2OS cells[1].
SMIFH2 (25 μM) reduces p300, mDia2 and p53 levels in a proteasome-independent manner[1].
SMIFH2 reduces expression and activity of p53 through a post-transcriptional, proteasome-independent mechanism that influences remodelling of the cytoskeleton[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: 293T, A375, U2OS, and MDA-MB-231 cells
Concentration: 25 μM
Incubation Time: 5 hours for 293T, U2OS, MDA-MB-231 cells; 2.5 hours for A375 cells
Result: Downregulated mDia2, p53 and p300 protein levels.
Molecular Weight

377.21

Formula

C₁₅H₉BrN₂O₃S

CAS No.

340316-62-3

SMILES

O=C(/C(C(N1C2=CC=CC(Br)=C2)=O)=C\C3=CC=CO3)NC1=S

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SMIFH2SMIFH 2SMIFH-2OthersHeLalungadenocarcinomaepithelialbreastcarcinomaforminactinpolymerizationcytoskeletonInhibitorinhibitorinhibit

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SMIFH2
Cat. No.:
HY-16931
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