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aura

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By Targets:	5-HT Receptor (2) Aurora Kinase (3) IGF-1R (1) Insulin Receptor (1) PKC (1)
By Research Areas:	Cancer (4) Endocrinology (1) Neurological Disease (2)

6

Inhibitors & Agonists

2

Recombinant Proteins

1

Isotope-Labeled Compounds

1

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

LY3295668 1 Publications Verification AK-01	Aurora Kinase	Cancer
LY3295668 (AK-01) is a potent, orally active and highly specific Aurora-A kinase inhibitor, with K_i values of 0.8 nM and 1038 nM for AurA and AurB, respectively.

AKI603	Aurora Kinase	Cancer
AKI603 is an inhibitor of Aurora kinase A (AurA), with an IC₅₀ of 12.3 nM. AKI603 is developed to overcome resistance mediated by BCR-ABL-T315I mutation. AKI603 exhibits strong anti-proliferative activity in leukemic cells .

Frovatriptan (R)-Frovatriptan; SB 209509; VML 251	5-HT Receptor	Neurological Disease
Frovatriptan is a potent 5-HT_1B//D receptor agonist and has the highest 5-HT_1B potency in the triptan class. Frovatriptan is apparently cerebroselective. Frovatriptan is efficacious and even superior in some endpoints also when taken during the headache phase in migraine attacks with aura .

Aurora A/PKC-IN-1	Aurora Kinase PKC	Cancer
Aurora A/PKC-IN-1 (Compound 2e) is a potent dual inhibitor of Aurora A (AurA) and PKC (α, β1, β2, and θ) kinases with IC₅₀s of 6.9 nM and 16.9 nM for AurA and PKCα, respectively. Aurora A/PKC-IN-1 has antiproliferative activity in breast cancer cells and antimetastatic activity .

Frovatriptan-d3 hydrochloride (R)-Frovatriptan-d₃ hydrochloride; SB 209509-d₃ hydrochloride; VML 251-d₃ hydrochloride	5-HT Receptor	Neurological Disease
Frovatriptan-d₃ (hydrochloride) is the deuterium labeled Frovatriptan[1]. Frovatriptan is a potent 5-HT1B//D receptor agonist and has the highest 5-HT1B potency in the triptan class. Frovatriptan is apparently cerebroselective. Frovatriptan is efficacious and even superior in some endpoints also when taken during the headache phase in migraine attacks with aura[2].

BMS-754807 5+ Cited Publications	IGF-1R Insulin Receptor	Endocrinology Cancer
BMS-754807 is a potent and reversible IGF-1R/IR inhibitor (IC₅₀=1.8 and 1.7 nM, respectively; K_i=<2 nM for both). BMS-754807 also shows potent activities against Met, RON, TrkA, TrkB, AurA, and AurB with IC₅₀ values of 6, 44, 7, 4, 9, and 25 nM, respectively .

Species:	Human (2)
Tag:	His (1) Tag Free (1) GST (1) Flag (1)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P702672

AURKA Protein, Human (sf9, GST)

AURKA; aurora kinase A; AIK; ARK1; aura; BTAK; STK6; STK7; STK15; PPP1R47
Human Sf9 insect cells

	AURA Protein, Human (Sf9) AURKA; Aurora kinase A; Aurora 2; Aurora/IPL1-related kinase 1; ARK-1; Aurora-related kinase 1; hARK1; Breast tumor-amplified kinase; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A	Human	Sf9 insect cells
	AURA is a mitotic serine/threonine kinase that complexly controls cell cycle progression and various mitotic events. AURA associates with centrosomes and spindle microtubules during mitosis and plays a critical role in spindle establishment, centrosome duplication, chromosome alignment, spindle assembly checkpoint activation, and cytokinesis. AURA Protein, Human (Sf9) is the recombinant human-derived AURA protein, expressed by Sf9 insect cells , with tag free. The total length of AURA Protein, Human (Sf9) is 402 a.a., .

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