2. Cell Cycle/DNA Damage Epigenetics TGF-beta/Smad
  3. Aurora Kinase PKC
  4. Aurora A/PKC-IN-1

Aurora A/PKC-IN-1 (Compound 2e) is a potent dual inhibitor of Aurora A (AurA) and PKC (α, β1, β2, and θ) kinases with IC50s of 6.9 nM and 16.9 nM for AurA and PKCα, respectively. Aurora A/PKC-IN-1 has antiproliferative activity in breast cancer cells and antimetastatic activity.

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Aurora A/PKC-IN-1

Aurora A/PKC-IN-1 Chemical Structure

CAS No. : 3031505-76-4

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Other Forms of Aurora A/PKC-IN-1:

Aurora A/PKC-IN-1 Related Antibodies

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Description

Aurora A/PKC-IN-1 (Compound 2e) is a potent dual inhibitor of Aurora A (AurA) and PKC (α, β1, β2, and θ) kinases with IC50s of 6.9 nM and 16.9 nM for AurA and PKCα, respectively. Aurora A/PKC-IN-1 has antiproliferative activity in breast cancer cells and antimetastatic activity[1].

IC50 & Target[1]

Aurora A

6.9 nM (IC50)

PKCα

16.9 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
4T1 IC50
0.8 μM
Compound: 2e
Cytotoxicity against mouse 4T1 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Cytotoxicity against mouse 4T1 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
[PMID: 35167283]
MDA-MB-231 IC50
1.2 μM
Compound: 2e
Cytotoxicity against human MDA-MB-231/M cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Cytotoxicity against human MDA-MB-231/M cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
[PMID: 35167283]
Molecular Weight

464.24

Formula

C16H14N6OSe2
CAS No.
SMILES

O=C1N(C2=NC(N[C@@H]3C[Se]CC3)=C4N=CNC4=N2)[Se]C5=C1C=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Aurora A/PKC-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aurora A/PKC-IN-13031505-76-4Aurora KinasePKCProtein kinase CAurora Aantiproliferativemetastatic breast cancer cellsantimetastaticInhibitorinhibitorinhibit

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