Aurora A/PKC-IN-1
Aurora A/PKC-IN-1 (Compound 2e) is a potent dual inhibitor of Aurora A (AurA) and PKC (α, β1, β2, and θ) kinases with IC50s of 6.9 nM and 16.9 nM for AurA and PKCα, respectively. Aurora A/PKC-IN-1 has antiproliferative activity in breast cancer cells and antimetastatic activity.
For research use only. We do not sell to patients.
- CAS No.: 3031505-76-4
- Formula: C16H14N6OSe2
- Molecular Weight:464.24
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Aurora Kinase Isoforms
More
Biological Activity
|
Aurora A 6.9 nM (IC50) |
PKCα 16.9 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| 4T1 | IC50 |
0.8 μM
Compound: 2e
|
Cytotoxicity against mouse 4T1 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Cytotoxicity against mouse 4T1 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
|
[PMID: 35167283] |
| MDA-MB-231 | IC50 |
1.2 μM
Compound: 2e
|
Cytotoxicity against human MDA-MB-231/M cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
Cytotoxicity against human MDA-MB-231/M cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
|
[PMID: 35167283] |
Chemical Information
-
CAS No. 3031505-76-4
-
Molecular Weight 464.24
-
Formula C16H14N6OSe2
-
SMILES
O=C1N(C2=NC(N[C@@H]3C[Se]CC3)=C4N=CNC4=N2)[Se]C5=C1C=CC=C5
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)