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cholesteryl ester hydrolase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Carboxylesterase (CES) (1) Apoptosis (1) Calcium Channel (1) Ferroptosis (1) Free Fatty Acid Receptor (1) Mitochondrial Metabolism (1) Reactive Oxygen Species (ROS) (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (2)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Targets Recommended: CETP Hormone-Sensitive Lipase (HSL) Carboxylesterase (CES) Epoxide Hydrolase FAAH S-adenosylhomocysteine hydrolase (SAHH) OGA

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-110390

GR148672X	Carboxylesterase (CES) Free Fatty Acid Receptor Reactive Oxygen Species (ROS) Mitochondrial Metabolism Ferroptosis Apoptosis	Cardiovascular Disease Cancer
GR148672X is an inhibitor of carboxylesterase 1 (CES1) and hepatic microsomal triglyceride hydrolase (TGH). GR148672X blocks the catalytic activity of CES1, impairs the functions of triglyceride and cholesteryl ester lipase, reduces triglyceride mobilization and secretion, and decreases apolipoprotein B-100 secretion in primary rat hepatocytes. Under low-glucose conditions, GR148672X inhibits the survival of colorectal cancer cells by reducing free fatty acid availability, inducing toxic triglyceride accumulation, ROS production, mitochondrial damage, ferroptosis and apoptosis. GR148672X can be used in studies related to colorectal cancer and atherosclerosis .

HY-183907

Cicletanine	Calcium Channel	Cardiovascular Disease
Cicletanine is a voltage-dependent Ca ²⁺ channel inhibitor. Cicletanine inhibits α-adrenoceptor-mediated Ca ²⁺ release pathway, and shows vasodilatory effects on isolated vascular smooth muscle. Cicletanine directly stimulates lysosomal and cytoplasmic cholesteryl ester hydrolase activity. Cicletanine can be used for the research of hypertension .

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HY-P703648

	LIPA Protein, Human (P. pastoris, His) Lysosomal acid lipase/cholesteryl ester hydrolase; cholesteryl esterase; Diacylglycerol lipase; Sterol esterase	Human	P. pastoris
	LIPA Protein, Human (P. pastoris, His) is the recombinant human-derived LIPA protein, expressed by P. pastoris, with N-6*His tag.

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Host:	Mouse (2)
Reactivity:	Human (2)
Application:	WB (2) ELISA (2)
Isotype:	IgG2a (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1)
Modification:	Unmodified (1)

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HY-P85252

	LAL Antibody (YA4944) LIPA; Lysosomal acid lipase/cholesteryl ester hydrolase; Acid cholesteryl ester hydrolase; LAL; cholesteryl esterase; Lipase A; Sterol esterase	WB, ELISA	Human
	LAL Antibody (YA4944) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to LAL.

HY-P85252A

	LAL Antibody (YA4944)(PBS only) LIPA; Lysosomal acid lipase/cholesteryl ester hydrolase; Acid cholesteryl ester hydrolase; LAL; cholesteryl esterase; Lipase A; Sterol esterase	WB, ELISA	Human
	LAL Antibody (YA4944) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to LAL.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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