electrophile

By Targets:	ADC Cytotoxin (2) Apoptosis (1) Biochemical Assay Reagents (2) Dipeptidyl Peptidase (1) DNA Alkylator/Crosslinker (2) EGFR (1) Ferroptosis (1) Fluorescent Dye (2) Glucosidase (1) Glutathione Peroxidase (2) Protein Arginine Deiminase (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Inflammation/Immunology (1)
Click Chemistry:	Alkynes (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138065

Iodoacetyl-LC-biotin	Apoptosis	Others
Iodoacetyl-LC-biotin is a biotinylated electrophile probe that can be used to investigate the scope and characteristics of protein covalent binding to subcellular proteomes .

HY-18408

5S rRNA modificator FAI	Biochemical Assay Reagents	Others
5S rRNA modificator is a suitable electrophile for 2’-hydroxyl acylation on structured RNA molecules, yielding accurate structural information comparable to that obtained with existing probes; 5S rRNA RNA modification.

HY-151212

BCP-T.A	Ferroptosis Glutathione Peroxidase	Cancer
BCP-T.A, a tunable heterocyclic electrophile, is a potent ferroptosis inducer by binding to GPX4 . BCP-T.A is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-116879

4-Oxo-2-Nonenal Alkyne (2E)-4-Oxo-2-nonen-8-ynal; alkynyl-4-ONE	Others	Cancer
4-Oxo-2-Nonenal Alkyne ((2E)-4-Oxo-2-nonen-8-ynal; alkynyl-4-ONE) is a functionalized lipid electrophile that conjugated to the exosomes via the reaction of amino and aldehyde groups. 4-Oxo-2-Nonenal Alkyne can be used in tumor exosomes determination .

HY-130978

Duocarmycin DM	DNA Alkylator/Crosslinker ADC Cytotoxin	Cancer
Duocarmycin DM, a DNA minor-groove alkylator, is an antibody agent conjugates (ADCs) toxin. Duocarmycin DM is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity .

HY-157919

Biotin-PEAC5-maleimide hydrochloride N-6-(Biotinylamino)hexanoyl-N'-[2-(N-maleimido)ethyl]piperazine, hydrochloride	Biochemical Assay Reagents	Others
Biotin-PEAC5-maleimide hydrochloride is a biochemical assay reagent, and can be used in biotin-PEAC5-maleimide (BPM)-labeling assay to assess modification of protein thiols by electrophiles .

HY-D1665

BDP 558/568 amine	Fluorescent Dye	Others
BDP 558/568 amine is an amine derivative of BDP 558/568. BDP 558/568 is a borondipyrromethene dye with yellow/orange emission. BDP 558/568 amine can be conjugated by means of reactions with various electrophiles .

HY-128915

Duocarmycin DM free base	DNA Alkylator/Crosslinker ADC Cytotoxin	Cancer
Duocarmycin DM free base, a DNA minor-groove alkylator, is an antibody agent conjugates (ADCs) toxin. Duocarmycin DM free base is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity .

HY-135304

PAD-IN-2	Protein Arginine Deiminase	Inflammation/Immunology Cancer
PAD-IN-2 is a potent pad4 inhibitor (IC₅₀: <1 μM). PAD-IN-2 can be used in the research of auto-immune diseases and cancers, such as rheumatoid arthritis, vasculitis, systemic lupus erythematosis, cutaneous lupus erythematosis, ulcerative colitis, cystic fibrosis, asthma, multiple sclerosis and psoriasis .

HY-19985A

(3S,4S)-PF-06459988	EGFR	Cancer
(3S, 4S)-PF-06459988 is the S enantiomer of PF-06459988 with less active. PF-06459988 is a potent irreversible inhibitor of T790M mutant epidermal growth factor receptor (EGFR). PF-06459988 has excellent selectivity against EGFR wild-type while possessing a minimally reactive electrophile that reduces the propensity of off-target labeling .

HY-163332

MPO-IN-6	Glucosidase Dipeptidyl Peptidase Glutathione Peroxidase	Cardiovascular Disease
MPO-IN-6 (compound ADC) is an electrophile with good antioxidant and anti-inflammatory properties. MPO-IN-6 is a myeloperoxidase (MPO), dipeptidyl peptidase-4 (DPP-4), and α-glucosidase (α-GD) inhibitor with IC₅₀s of 10 μM, 31.02 μM, and 46.05 μM, respectively. MPO-IN-6 is a potential cardiovascular preventive agent .

HY-D1376A

Sulfo-Cyanine5.5 amine	Fluorescent Dye	Others
Sulfo-Cyanine5.5 amine consists of four sulfonate groups and has highly hydrophilic. Sulfo-Cyanine5.5 amine is an amine-containing fluorescent dye, the aliphatic primary amine group can be coupled with various electrophiles (activated esters, epoxides, etc). Sulfo-Cyanine5.5 amine can be used for the research of far red/NIR applications (such as in vivo imaging) and also can be used for enzymatic transamination labeling .

Cat. No.	Product Name	Type

HY-D1665

BDP 558/568 amine	Fluorescent Dyes/Probes
BDP 558/568 amine is an amine derivative of BDP 558/568. BDP 558/568 is a borondipyrromethene dye with yellow/orange emission. BDP 558/568 amine can be conjugated by means of reactions with various electrophiles .

HY-D1376A

Sulfo-Cyanine5.5 amine	Fluorescent Dyes/Probes
Sulfo-Cyanine5.5 amine consists of four sulfonate groups and has highly hydrophilic. Sulfo-Cyanine5.5 amine is an amine-containing fluorescent dye, the aliphatic primary amine group can be coupled with various electrophiles (activated esters, epoxides, etc). Sulfo-Cyanine5.5 amine can be used for the research of far red/NIR applications (such as in vivo imaging) and also can be used for enzymatic transamination labeling .

Sulfo-Cyanine5.5 amine

Fluorescent Dyes/Probes

Sulfo-Cyanine5.5 amine consists of four sulfonate groups and has highly hydrophilic. Sulfo-Cyanine5.5 amine is an amine-containing fluorescent dye, the aliphatic primary amine group can be coupled with various electrophiles (activated esters, epoxides, etc). Sulfo-Cyanine5.5 amine can be used for the research of far red/NIR applications (such as in vivo imaging) and also can be used for enzymatic transamination labeling .

Cat. No.	Product Name	Type

HY-157919

Biotin-PEAC5-maleimide hydrochloride N-6-(Biotinylamino)hexanoyl-N'-[2-(N-maleimido)ethyl]piperazine, hydrochloride	Biochemical Assay Reagents
Biotin-PEAC5-maleimide hydrochloride is a biochemical assay reagent, and can be used in biotin-PEAC5-maleimide (BPM)-labeling assay to assess modification of protein thiols by electrophiles .

Cat. No.	Product Name		Classification

HY-151212

BCP-T.A		Alkynes
BCP-T.A, a tunable heterocyclic electrophile, is a potent ferroptosis inducer by binding to GPX4 . BCP-T.A is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
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Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Click Chemistry