1. Cell Cycle/DNA Damage
    Antibody-drug Conjugate/ADC Related
  2. DNA Alkylator/Crosslinker
    ADC Cytotoxin
  3. Duocarmycin

Duocarmycin 

Cat. No.: HY-128915
Handling Instructions

Duocarmycin, a DNA minor-groove alkylator, is an antibody drug conjugates (ADCs) toxin. Duocarmycin is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity.

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Duocarmycin Chemical Structure

Duocarmycin Chemical Structure

CAS No. : 1116745-06-2

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Description

Duocarmycin, a DNA minor-groove alkylator, is an antibody drug conjugates (ADCs) toxin. Duocarmycin is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity[1][2].

IC50 & Target[1]

Daunorubicins/Doxorubicins

 

In Vitro

The Duocarmycins and CC-1065 are members of a class of DNA minor groove, AT-sequence selective, and adenine-N3 alkylating agents, isolated from Streptomyces sp. that exhibit extremely potent cytotoxicity against the growth of cancer cells grown in culture[2].
Duocarmycin shows cytotoxicity to several human cancer cells, with IC50 of 22, 13.8, 3.87, 15.4, and 7.31 pM for HT-29, CL1-5, Caski, EJ, and LS174T, respectively[3].

Molecular Weight

463.96

Formula

C₂₆H₂₆ClN₃O₃

CAS No.

1116745-06-2

SMILES

O=C(N1C[[email protected]@H](CCl)C2=C1C=C(O)C3=CC=CC=C23)C(N4)=CC5=C4C=CC(OCCN(C)C)=C5

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DuocarmycinDNA Alkylator/CrosslinkerADC CytotoxinDNAminor-groovecytotoxicitycancerHT-29cellsInhibitorinhibitorinhibit

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Duocarmycin
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