1. Apoptosis
    Metabolic Enzyme/Protease
  2. Ferroptosis
    Glutathione Peroxidase
  3. BCP-T.A

BCP-T.A 

Cat. No.: HY-151212
Handling Instructions

BCP-T.A, a tunable heterocyclic electrophile, is a potent ferroptosis inducer by binding to GPX4.

For research use only. We do not sell to patients.

BCP-T.A Chemical Structure

BCP-T.A Chemical Structure

CAS No. : 2786829-70-5

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Description

BCP-T.A, a tunable heterocyclic electrophile, is a potent ferroptosis inducer by binding to GPX4[1].

IC50 & Target

GPX4[1]

In Vitro

BCP-T.A induces ferroptosis in various cell lines (NCI-H522, T-1080, MDA-MB-468, MDA-MB-231, HeLa, HCT-116, U2OS, WI-38, and MEFS) with IC50 values of 10 nM-367 nM[1].
BCP-T.A (0.5 μM, 3 h) binds to GPX4 and increases lipid peroxides, indicated by cellular thermal shift assay (CETSA)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

456.39

Formula

C23H19Cl2N3OS

CAS No.
SMILES

O=C(N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1)C4=CSC(C#C)=N4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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