Iodoacetyl-LC-biotin
Based on 1 Customer Validation
Iodoacetyl-LC-biotin is a biotinylated electrophile probe that can be used to investigate the scope and characteristics of protein covalent binding to subcellular proteomes.
For research use only. We do not sell to patients.
- Purity: 99.47%
- CAS No.: 93285-75-7
- Formula: C18H31IN4O3S
- Molecular Weight:510.43
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Iodoacetyl-LC-biotin (IAB) (50-200 μM; 6-24 h) increases LDH leakage in HEK293 cells in a time- and dose-dependant manner[1].
IAB (50-200 µM; 24 h) causes the release of cytochrome c from the mitochondria to the cytosol in HEK293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 93285-75-7
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Appearance Solid
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Molecular Weight 510.43
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Formula C18H31IN4O3S
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Color White to off-white
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SMILES
O=C(NCCCCCCNC(CI)=O)CCCC[C@H]1[C@](NC2=O)([H])[C@](N2)([H])CS1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 20 mg/mL (39.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Wong HL, et, al. Mitochondrial protein targets of thiol-reactive electrophiles. Chem Res Toxicol. 2008 Apr;21(4):796-804. [Content Brief]
[2]. Davis KA, et, al. Staining of cell surface human CD4 with 2'-F-pyrimidine-containing RNA aptamers for flow cytometry. Nucleic Acids Res. 1998 Sep 1;26(17):3915-24. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9591 mL | 9.7957 mL | 19.5913 mL | 48.9783 mL |
| 5 mM | 0.3918 mL | 1.9591 mL | 3.9183 mL | 9.7957 mL | |
| 10 mM | 0.1959 mL | 0.9796 mL | 1.9591 mL | 4.8978 mL | |
| 15 mM | 0.1306 mL | 0.6530 mL | 1.3061 mL | 3.2652 mL | |
| 20 mM | 0.0980 mL | 0.4898 mL | 0.9796 mL | 2.4489 mL | |
| 25 mM | 0.0784 mL | 0.3918 mL | 0.7837 mL | 1.9591 mL | |
| 30 mM | 0.0653 mL | 0.3265 mL | 0.6530 mL | 1.6326 mL |
Iodoacetyl-LC-biotin Related Classifications
HY-138065 Related Classifications
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