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folate receptor (FR)-positive tumors

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Nombre del producto Target Áreas de investigación Chemical Structure
  • HY-16181
    EC-0225

    		Folate Receptor (FR) Microtubule/Tubulin DNA Alkylator/Crosslinker Cancer
    EC-0225, a folate conjugate of two agents- one a potent microtubule inhibiting agent, and the second a DNA alkylating agent. EC-0225 inhibits the growth of folate receptor (FR)-positive KB cells with an IC50 of ~1 nM. EC-0225 can be selectively delivered to advanced FR-positive tumors without causing overt toxicity, such as lung carcinoma .
    EC-0225
  • HY-129880
    Desacetylvinblastine hydrazide

    Deacetylvinblastine hydrazide; DAVLBH

    		 Microtubule/Tubulin Cancer
    Desacetylvinblastine hydrazide (Deacetylvinblastine hydrazide; DAVLBH) is an active component of EC145, a folate-targeted drug conjugate. Desacetylvinblastine hydrazide interferes with the formation of the mitotic spindle, and thus inhibits cell division and leads to cell death. Desacetylvinblastine hydrazide exhibits antitumor activity against folate receptor (FR)-positive tumor .
    Desacetylvinblastine hydrazide

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