Desacetylvinblastine hydrazide
Desacetylvinblastine hydrazide (Deacetylvinblastine hydrazide; DAVLBH) is an active component of EC145, a folate-targeted drug conjugate. Desacetylvinblastine hydrazide interferes with the formation of the mitotic spindle, and thus inhibits cell division and leads to cell death. Desacetylvinblastine hydrazide exhibits antitumor activity against folate receptor (FR)-positive tumor.
For research use only. We do not sell to patients.
- CAS No.: 55383-37-4
- Formula: C43H56N6O7
- Molecular Weight:768.94
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | IC50 |
0.03 μg/mL
Compound: 6
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In vitro inhibition of CCRF-CEM human leukemic lymphoblasts proliferation was determined
In vitro inhibition of CCRF-CEM human leukemic lymphoblasts proliferation was determined
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[PMID: 2783975] |
| LNCaP | IC50 |
12.2 nM
Compound: DAVBH
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Cytotoxicity against human LNCAP cells
Cytotoxicity against human LNCAP cells
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[PMID: 20936874] |
| T222 | IC50 |
3 ng/mL
Compound: DAVLB hydrazide
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Concentration for 50% growth inhibition relative to untreated control in the human lung epidermoid carcinoma (T222) cell line
Concentration for 50% growth inhibition relative to untreated control in the human lung epidermoid carcinoma (T222) cell line
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[PMID: 8295210] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 55383-37-4
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Molecular Weight 768.94
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Formula C43H56N6O7
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SMILES
CC[C@@]12[C@@]3([H])[C@@]4(CCN3CC=C2)C5=CC([C@@]6(C7=C(CC[N@@]8C[C@](C[C@](O)(C8)CC)([H])C6)C9=CC=CC=C9N7)C(OC)=O)=C(OC)C=C5N([C@@]4([H])[C@](O)([C@@H]1O)C(NN)=O)C
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Synonyms
Deacetylvinblastine hydrazide; DAVLBH
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Desacetylvinblastine hydrazide Related Classifications
HY-129880 Related Classifications
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