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Isoforms Recommended:	TRPV1

Results for "

hTRPV1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cannabinoid Receptor (1) Isotope-Labeled Compounds (1) Reference Standards (1) TRP Channel (7)
By Research Areas:	Neurological Disease (6)

Inhibitors & Agonists

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16935

Mavatrep JNJ-39439335	TRP Channel	Neurological Disease
Mavatrep (JNJ-39439335) is an orally active, selective and potent *TRPV1* antagonist with high affinity for *hTRPV1* channels (K_i=6.5 nM). Mavatrep antagonizes capsaicin-induced Ca ²⁺ influx with an IC₅₀ value of 4.6 nM. Mavatrep can be used in some studies of neuropathic pain ^[1].

HY-136363

MDR-652	TRP Channel	Neurological Disease
MDR-652 is a highly specific and efficacious transient receptor potential vanilloid 1 (TRPV1) ligand with agonist activity. The K_is are 11.4 and 23.8 nM for hTRPV1 and rTRPV1, respectively. The EC₅₀s are 5.05 and 93 nM for hTRPV1 and rTRPV1, respectively. Potent topical analgesic activity ^[1].

HY-162908

TRPV1/CB2 agonist 1	TRP Channel Cannabinoid Receptor	Neurological Disease
TRPV1/CB2 agonist 1 (compound 41) is a *TRPV1/CB2* agonist, with an EC₅₀ of 26.8 μM for hTRPV1. TRPV1/CB2 agonist 1 can be used in nervous system related research ^[1].

HY-16935S

Mavatrep-d6 JNJ-39439335-d₆	Isotope-Labeled Compounds TRP Channel	Neurological Disease
Mavatrep-d₆ (JNJ-39439335-d₆) is a deuterated labeled Mavatrep (HY-16935). Mavatrep (JNJ-39439335) is an orally active, selective and potent TRPV1 antagonist with high affinity for hTRPV1 channels (K_i=6.5 nM). Mavatrep antagonizes capsaicin-induced Ca ²⁺ influx with an IC₅₀ value of 4.6 nM. Mavatrep can be used in some studies of neuropathic pain ^[1].

HY-16935R

Mavatrep (Standard) JNJ-39439335 (Standard)	TRP Channel Reference Standards	Neurological Disease
Mavatrep (Standard) is the analytical standard of Mavatrep. This product is intended for research and analytical applications. Mavatrep (JNJ-39439335) is an orally active, selective and potent TRPV1 antagonist with high affinity for hTRPV1 channels (Ki=6.5 nM). Mavatrep antagonizes capsaicin-induced Ca2+ influx with an IC50 value of 4.6 nM. Mavatrep can be used in some studies of neuropathic pain ^[1].

HY-183281

TRPV3 antagonist-1	TRP Channel	Others
TRPV3 antagonist-1 is a selective *TRPV3* channel antagonist with an IC₅₀ of 11.97 μM. TRPV3 antagonist-1 shows selectivity over *hTRPV1, hTRPV4, hTRPA1, and hTRPM8. TRPV3 antagonist*-1 shows low cytotoxicity ^[1].

HY-175980

TRPA1 agonist-3	TRP Channel	Neurological Disease
TRPA1 agonist-3 is a selective and orally active *TRPA1* agonist, with EC₅₀ values of 50.05 μM and 314.04 μM for human and mouse TRPA1, respectively. TRPA1 agonist-3 does not activate hTRPV1, mTRPV2, hTRPV3, hTRPV4, hTRPC6, or hTRPM8 channels. TRPA1 agonist-3 alleviates inflammatory pain in mice through a channel desensitization mechanism ^[1].

Cat. No.	Product Name	Chemical Structure

HY-16935S

Mavatrep-d6
Mavatrep-d₆ (JNJ-39439335-d₆) is a deuterated labeled Mavatrep (HY-16935). Mavatrep (JNJ-39439335) is an orally active, selective and potent TRPV1 antagonist with high affinity for hTRPV1 channels (K_i=6.5 nM). Mavatrep antagonizes capsaicin-induced Ca ²⁺ influx with an IC₅₀ value of 4.6 nM. Mavatrep can be used in some studies of neuropathic pain ^[1].

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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