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Cat. No.: HY-183281

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TRPV3 antagonist-1

TRPV3 antagonist-1 is a selective TRPV3 channel antagonist with an IC₅₀ of 11.97 μM. TRPV3 antagonist-1 shows selectivity over hTRPV1, hTRPV4, hTRPA1, and hTRPM8. TRPV3 antagonist-1 shows low cytotoxicity.

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Formule: C₂₂H₁₉NO₄
Masse moléculaire:361.39

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

TRPV3 antagonist-1 Chemical Structure

Stock

Quantité

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

^[1]

TRPV3

11.97 μM (IC₅₀)

Voir tous les produits spécifiques à Isoform TRP Channel :

In Vitro

TRPV3 antagonist-1 (compound 7-9) (100 μM) selectively inhibits hTRPV3 channels in HEK293T cells over hTRPV1, hTRPV4, hTRPA1, and hTRPM8^[1].
TRPV3 antagonist-1 (3-300 μM; 48-72 h) exhibits low cytotoxicity toward A549 cells^[1].
TRPV3 antagonist-1 binds to TRPV3 through multiple hydrogen bonding and π-π stacking interactions^[1].
TRPV3 antagonist-1 (50 μM) inhibits the single-channel currents induced by 2-APB (30 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

A549 cells
Concentration:

3; 30; 300 μM
Incubation Time:

48; 72 h
Result:

Showed no significant antiproliferative activity at 3, 30, or 300 μM after 48 h.
Exhibited a maximum inhibition rate of 19.5% at 300 μM after 72 h.

Related Protocols :

Chemical Information

Masse moléculaire 361.39
Formule C₂₂H₁₉NO₄
SMILES

OC1=C(C(O)=O)C(CCC2=CC=C(NC(C3=CC=CC=C3)=O)C=C2)=CC=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Hou F, et al. Discovery of novel TRPV3 antagonists with o-hydroxybenzoic acid as the core skeleton. Eur J Med Chem. 2026;312:118873. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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