TRPV3 antagonist-1
TRPV3 antagonist-1 is a selective TRPV3 channel antagonist with an IC50 of 11.97 μM. TRPV3 antagonist-1 shows selectivity over hTRPV1, hTRPV4, hTRPA1, and hTRPM8. TRPV3 antagonist-1 shows low cytotoxicity.
For research use only. We do not sell to patients.
- Formula: C22H19NO4
- Molecular Weight:361.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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TRPV3 11.97 μM (IC50) |
TRPV3 antagonist-1 (compound 7-9) (100 μM) selectively inhibits hTRPV3 channels in HEK293T cells over hTRPV1, hTRPV4, hTRPA1, and hTRPM8[1].
TRPV3 antagonist-1 (3-300 μM; 48-72 h) exhibits low cytotoxicity toward A549 cells[1].
TRPV3 antagonist-1 binds to TRPV3 through multiple hydrogen bonding and π-π stacking interactions[1].
TRPV3 antagonist-1 (50 μM) inhibits the single-channel currents induced by 2-APB (30 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 cells
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Concentration:3; 30; 300 μM
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Incubation Time:48; 72 h
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Result:Showed no significant antiproliferative activity at 3, 30, or 300 μM after 48 h.
Exhibited a maximum inhibition rate of 19.5% at 300 μM after 72 h.
Chemical Information
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Molecular Weight 361.39
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Formula C22H19NO4
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SMILES
OC1=C(C(O)=O)C(CCC2=CC=C(NC(C3=CC=CC=C3)=O)C=C2)=CC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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