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iris sphincter muscle

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-116161A
    17-Phenyl trinor PGF2α isopropyl ester

    		Prostaglandin Receptor Metabolic Disease
    17-Phenyl trinor PGF2α isopropyl ester is a FP receptor agonist and intraocular pressure-lowering agent. 17-Phenyl trinor PGF2α isopropyl ester induces iris sphincter contraction, reduces intraocular pressure and pupil diameter, causes no ocular irritation, and only leads to mild conjunctival hyperemia. 17-Phenyl trinor PGF2α isopropyl ester is applicable to relevant research on glaucoma .
    17-Phenyl trinor PGF2α isopropyl ester
  • HY-116161
    Bimatoprost isopropyl ester

    		Drug Intermediate Cardiovascular Disease Others
    15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester (15(R)-17-phenyl trinor PGF2α isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (β) hydroxyl group at C-15. Similar to 15(S)-latanoprost, 15(R)-17-phenyl trinor PGF2α isopropyl ester is a potential impurity in most commercial preparations of the latanoprost bulk drug product. The IC50 values for the free acid forms of 15(S)-17-phenyl trinor PGF2α and 15(R)-17-phenyl trinor PGF2α were determined to be 0.71 nM and 30 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle.1 A 3 μg dose of 15(R)-17-phenyl trinor PGF2α caused a 1.9 mmHg reduction of IOP in normotensive cynomolgus monkeys.
    Bimatoprost isopropyl ester
  • HY-126115
    15(S)-Latanoprost

    15-epi Latanoprost

    		 Prostaglandin Receptor Cardiovascular Disease Others
    15(S)-Latanoprost is an analog of latanoprost in which the hydroxyl at carbon 15 is inverted relative to latanoprost. The IC50 values for the free acid forms of latanoprost and 15(S)-latanoprost were determined to be 3.6 nM and 24 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle. A 3 μg dose of 15(S)-latanoprost caused a 1 mmHg reduction of IOP in normotensive cynomolgus monkeys.
    15(S)-Latanoprost
  • HY-126115R
    15(S)-Latanoprost (Standard)

    15-epi Latanoprost (Standard)

    		 Prostaglandin Receptor Reference Standards Cardiovascular Disease Others
    15(S)-Latanoprost (Standard) is the analytical standard of 15(S)-Latanoprost. This product is intended for research and analytical applications. 15(S)-Latanoprost is an analog of latanoprost in which the hydroxyl at carbon 15 is inverted relative to latanoprost. The IC50 values for the free acid forms of latanoprost and 15(S)-latanoprost were determined to be 3.6 nM and 24 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle. A 3 μg dose of 15(S)-latanoprost caused a 1 mmHg reduction of IOP in normotensive cynomolgus monkeys.
    15(S)-Latanoprost (Standard)
  • HY-N7857
    19(R)-Hydroxy-prostaglandin F2α

    19(R)-Hydroxy PGF2α

    		 Drug Metabolite Metabolic Disease
    19(R)-Hydroxy-prostaglandin F2α (19(R)-hydroxy PGF2α) is an ω-1 hydroxylase metabolite of PGF2α found in human semen. The concentration of 19(R)-Hydroxy-PGFs compounds (F2α and F1α together) in fresh human semen is about 20 μg/mL. 19(R)-Hydroxy-prostaglandin F2α exhibits no activity at the FP receptor of the cat iris sphincter muscle at concentrations up to 1 μM.
    19(R)-Hydroxy-prostaglandin F2α

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