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By Targets:	Acetyl-CoA Carboxylase (1) Autophagy (1) CaMK (2) Fluorescent Dye (2) Histone Methyltransferase (2)
By Research Areas:	Cancer (2) Neurological Disease (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P0271A

Syntide 2 TFA 1 Publications Verification	CaMK	Neurological Disease
Syntide 2 (TFA), a Ca ²⁺- and calmodulin (CaM)-dependent protein kinase II (CaMKII) substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected .

HY-P0271

Syntide 2	CaMK Autophagy	Neurological Disease
Syntide 2, a Ca ²⁺- and calmodulin (CaM)-dependent protein kinase II (CaMKII) substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected .

HY-135753

Sethoxydim

BAS 9052
Acetyl-CoA Carboxylase Others

Sethoxydim is a postemergent herbicide. Sethoxydim inhibits plant acetyl-coenzyme A carboxylase (ACCase) activity .

Sethoxydim BAS 9052	Acetyl-CoA Carboxylase	Others
Sethoxydim is a postemergent herbicide. Sethoxydim inhibits plant acetyl-coenzyme A carboxylase (ACCase) activity .

HY-N11166

3,5,7,8,3′,4′-Hexamethoxyflavone	Others	Others
3,5,7,8,3′,4′-Hexamethoxyflavone is a flavonoid. 3,5,7,8,3′,4′-Hexamethoxyflavone can be isolated from the leaves of Melicope triphylla MERR .

HY-W250928C

Biotin-PEG-azide (MW 2000) Carbamic acid, N-(17-azido-3,6,9,12,15-pentaoxaheptadec-1-yl)-, 1,1-dimethylethyl ester	Fluorescent Dye	Others
Biotin-PEG-azide (MW 2000) is a biotin labeled PEG derivative. Biotin is an enzyme co-factor, can be used for labeling protein; PEG is a hydrophilic and water-soluble polymer with low toxicity; azide, is a moderately good leaving group, can react with alkyne by Cu-catalyzation, which improve the efficiency of biotin binding targets.

HY-W250928D

Biotin-PEG-azide (MW 3400) Carbamic acid, N-(17-azido-3,6,9,12,15-pentaoxaheptadec-1-yl)-, 1,1-dimethylethyl ester	Fluorescent Dye	Others
Biotin-PEG-azide (MW 3400) is a biotin labeled PEG derivative. Biotin is an enzyme co-factor, can be used for labeling protein; PEG is a hydrophilic and water-soluble polymer with low toxicity; azide, is a moderately good leaving group, can react with alkyne by Cu-catalyzation, which improve the efficiency of biotin binding targets.

HY-N10894

Murrayacarpin B

Others Others

Murrayacarpin B is a phenolic compound. Murrayacarpin B can be isolated from the leaves and fruits of F. carica .

Murrayacarpin B	Others	Others
Murrayacarpin B is a phenolic compound. Murrayacarpin B can be isolated from the leaves and fruits of F. carica .

HY-120137

CMP-5	Histone Methyltransferase	Cancer
CMP-5 is a potent, specific, and selective PRMT5 inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 prevents Epstein-Barr virus (EBV)-driven B-lymphocyte transformation but leaving normal B cells unaffected .

HY-113846

CMP-5 hydrochloride	Histone Methyltransferase	Cancer
CMP-5 hydrochloride is a potent, specific, and selective PRMT5 inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 hydrochloride selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 hydrochloride prevents EBV-driven B-lymphocyte transformation but leaving normal B cells unaffected .

Cat. No.	Product Name

HY-L011

Membrane Transporter/Ion Channel Compound Library	1392 compounds
Most of molecules enter or leave cells mainly via membrane transport proteins, which play important roles in several cellular functions, including cell metabolism, ion homeostasis, signal transduction, the recognition process in the immune system, energy transduction, etc. There are three major types of transport proteins, ATP-powered pumps, channel proteins and transporters. Transport proteins such as channels and transporters play important roles in the maintenance of intracellular homeostasis, and mutations in these transport protein genes have been identified in the pathogenesis of a number of hereditary diseases. In the central nervous system, ion channels have been linked to, but not limited to, many diseases such asataxias, paralyses, epilepsies, and deafness. This indicates the roles of ion channels in the initiation and coordination of movement, sensory perception, and encoding and processing of information. Ion channels are a major class of drug targets in drug development. MCE designs a unique collection of 1392 smal-molecule modulators that can be used for the research of Ion Channel and Membrane Transporter or high throughput screening (HTS) related drug discovery.

Membrane Transporter/Ion Channel Compound Library

1392 compounds

Most of molecules enter or leave cells mainly via membrane transport proteins, which play important roles in several cellular functions, including cell metabolism, ion homeostasis, signal transduction, the recognition process in the immune system, energy transduction, etc. There are three major types of transport proteins, ATP-powered pumps, channel proteins and transporters. Transport proteins such as channels and transporters play important roles in the maintenance of intracellular homeostasis, and mutations in these transport protein genes have been identified in the pathogenesis of a number of hereditary diseases. In the central nervous system, ion channels have been linked to, but not limited to, many diseases such asataxias, paralyses, epilepsies, and deafness. This indicates the roles of ion channels in the initiation and coordination of movement, sensory perception, and encoding and processing of information. Ion channels are a major class of drug targets in drug development.

MCE designs a unique collection of 1392 smal-molecule modulators that can be used for the research of Ion Channel and Membrane Transporter or high throughput screening (HTS) related drug discovery.

Cat. No.	Product Name	Target	Research Area

HY-P0271A

Syntide 2 TFA 1 Publications Verification	CaMK	Neurological Disease
Syntide 2 (TFA), a Ca ²⁺- and calmodulin (CaM)-dependent protein kinase II (CaMKII) substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected .

HY-P0271

Syntide 2	CaMK Autophagy	Neurological Disease
Syntide 2, a Ca ²⁺- and calmodulin (CaM)-dependent protein kinase II (CaMKII) substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N11166

3,5,7,8,3′,4′-Hexamethoxyflavone	Structural Classification Flavonoids Melicope triphylla (Lam.) Merr. Flavones Source classification Rutaceae Plants	Others
3,5,7,8,3′,4′-Hexamethoxyflavone is a flavonoid. 3,5,7,8,3′,4′-Hexamethoxyflavone can be isolated from the leaves of Melicope triphylla MERR .

HY-N10894

Murrayacarpin B	Structural Classification Ficus carica L. Source classification Phenols Plants Moraceae	Others
Murrayacarpin B is a phenolic compound. Murrayacarpin B can be isolated from the leaves and fruits of F. carica .

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
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