1. Neuronal Signaling
  2. CaMK

Syntide 2 (Synonyms: Pro-Leu-Ala-Arg-Thr-Leu-Ser-Val-Ala-Gly-Leu-Pro-Gly-Lys-Lys; PLARTLSVAGLPGKK)

Cat. No.: HY-P0271
Handling Instructions

Syntide 2 is recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII) with a Ki of 12 μM.

For research use only. We do not sell to patients.
Syntide 2 Chemical Structure

Syntide 2 Chemical Structure

CAS No. : 108334-68-5

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1 mg USD 84 Get quote
5 mg USD 288 Get quote
10 mg USD 456 Get quote

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  • Biological Activity

  • Protocol

  • Technical Information

  • References

Description

Syntide 2 is recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII) with a Ki of 12 μM.

IC50 & Target

Km: 12 μM (CaMKII)[1]

In Vitro

The sequence of syntide-2 (pro-leu-ala-arg-thr-leu-ser-val-ala-gly-leu-pro-gly-lys-lys) is homologous to phosphorylation site 2 in glycogen synthase. The relative Vmax/Km ratios of the known Ca2+-dependent protein kinases for syntide-2 are determined to be as follows: protein kinase II, 100; protein kinase C, 22; phosphorylase kinase, 2; myosin light chain kinase, 0.005[1].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 0.6632 mL 3.3160 mL 6.6321 mL
5 mM 0.1326 mL 0.6632 mL 1.3264 mL
10 mM 0.0663 mL 0.3316 mL 0.6632 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

1507.82

Formula

C₆₈H₁₂₂N₂₀O₁₈

CAS No.

108334-68-5

SMILES

O=C([[email protected]@H]1CCCN1)N[[email protected]@H](CC(C)C)C(N[[email protected]@H](C)C(N[[email protected]@H](CCCNC(N)=N)C(N[[email protected]]([[email protected]](O)C)([H])C(N[[email protected]@H](CC(C)C)C(N[[email protected]@H](CO)C(N[[email protected]@H](C(C)C)C(N[[email protected]@H](C)C(NCC(N[[email protected]@H](CC(C)C)C(N2[[email protected]@H](CCC2)C(NCC(N[[email protected]@H](CCCCN)C(N[[email protected]](C(O)=O)CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

H2O

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Syntide 2
Cat. No.:
HY-P0271
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